Intracerebral metastases medical therapy: Difference between revisions

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{{Intracerebral metastases}}
{{Intracerebral metastases}}
{{CMG}}{{AE}}{{SR}}


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==Overview==
==Overview==


==Medical Therapy==
==Medical Therapy==


'''Symptomatic:''' Corticosteroids are given to limit the effects of peritumoral edema. Hyperosmolar agents (eg mannitol) can be given to decrease ICP and anticonvulsants are given to prevent seizures. Recently, methylphenidate and donepezil have been used to improve cognition, mood and quality of life.
===Symptomatic Treatment===
*Corticosteroids are given to limit the effects of peritumoral edema.<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref> Hyperosmolar agents (eg mannitol) can be given to decrease ICP and anticonvulsants are given to prevent seizures. Recently, methylphenidate and donepezil have been used to improve cognition, mood and quality of life.
 
===Therapeutic===
====Radiation Therapy====
*The most widely used treatment for patients with multiple brain metastases is WBRT (whole brain external beam radiotherapy).<ref name="Khuntia2015">{{cite journal|last1=Khuntia|first1=Deepak|title=Contemporary Review of the Management of Brain Metastasis with Radiation|journal=Advances in Neuroscience|volume=2015|year=2015|pages=1–13|issn=2356-6787|doi=10.1155/2015/372856}}</ref>


'''Therapeutic:''' Radiation (whole brain external beam or stereotactic for smaller masses), chemotherapy and surgical resection are done to prolong survival and palliate symptoms. Other than germ cell tumors, leukemias and lymphomas, palliation is the rule and curative therapy is the subject of case reports.
*Stereotactic radiosurgery is done for smaller masses.


==References==
==References==

Revision as of 21:20, 9 November 2015

Intracerebral metastases Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]


Overview

Medical Therapy

Symptomatic Treatment

  • Corticosteroids are given to limit the effects of peritumoral edema.[1] Hyperosmolar agents (eg mannitol) can be given to decrease ICP and anticonvulsants are given to prevent seizures. Recently, methylphenidate and donepezil have been used to improve cognition, mood and quality of life.

Therapeutic

Radiation Therapy

  • The most widely used treatment for patients with multiple brain metastases is WBRT (whole brain external beam radiotherapy).[1]
  • Stereotactic radiosurgery is done for smaller masses.

References

  1. 1.0 1.1 Khuntia, Deepak (2015). "Contemporary Review of the Management of Brain Metastasis with Radiation". Advances in Neuroscience. 2015: 1–13. doi:10.1155/2015/372856. ISSN 2356-6787.


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