Metanephric adenoma pathophysiology: Difference between revisions
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==Genetics== | ==Genetics== | ||
* Allelic changes of a [[tumor suppressor gene]] on [[chromosome]] 2p13 may be involved in the pathogenesis of metanephric adenoma.<ref name="pmid11172302">{{cite journal |vauthors=Pesti T, Sükösd F, Jones EC, Kovacs G |title=Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping |journal=[[Human Pathology]] |volume=32 |issue=1 |pages=101–4 |year=2001 |pmid=11172302 |doi=10.1053/hupa.2001.21132 |url=http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(01)63640-2 |issn=}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 16:00, 9 November 2015
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Metanephric adenoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
On gross pathology, a sharply circumscribed, nonencapsulated solitary mass is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine chromatin and smooth nuclear membrane, variable architecture, and psammoma bodies are characteristic findings of metanephric adenoma.
Gross Pathology
Characteristic findings of metanephric adenoma on gross pathology include:[1]
- Solitary mass
- Sharply circumscribed
- Not encapsulated
Microscopic Pathology
The characteristics of metanephric adenomas include:[2]
- Small uniform cells with:
- Fine chromatin
- No apparent nucleolus
- Smooth nuclear membrane
- Variable architecture:
- May be sheets, ductal or micropapillary
- Psammoma bodies may present
-
![Metanephric adenoma[3]](/images/b/b2/Metanephric_adenoma1.jpg)
Metanephric adenoma[3]
![Metanephric adenoma[3]](/index.php/File:Metanephric_adenoma1.jpg)
Genetics
- Allelic changes of a tumor suppressor gene on chromosome 2p13 may be involved in the pathogenesis of metanephric adenoma.[4]
References
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Metanephric adenoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Metanephric_adenoma Accessed on November 9, 2015
- ↑ Pesti T, Sükösd F, Jones EC, Kovacs G (2001). "Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping". Human Pathology. 32 (1): 101–4. doi:10.1053/hupa.2001.21132. PMID 11172302.