Sandbox: DDx Kidney mass: Difference between revisions

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* Hyaline bodies common
* Hyaline bodies common


* Large heterogeneous mass
* Variable enhancement on CT due to necrosis
* Invasion of venous circulation


* Chromosome 3 mutation
* Chromosome 3 mutation

Revision as of 16:18, 9 November 2015

  • 60-70 male patients
  • Haematuria
  • Flank pain
  • Palpable flank mass
  • von Hippel-Lindau syndrome


  • Polygonal cells, clear cytoplasm, and a central nucleus
  • Delicate branching vasculature
  • "Chicken wire-like" vasculature
  • Hyaline bodies common


  • Large heterogeneous mass
  • Variable enhancement on CT due to necrosis
  • Invasion of venous circulation
  • Chromosome 3 mutation
  • VHL gene mutation
  • Gain of chromosome 5

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying