Sandbox: DDx Kidney mass: Difference between revisions
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* Areas of necrosis and cystic change | * Areas of necrosis and cystic change | ||
* on CT | * on CT | ||
* Polygonal cells, nuclear pleomorphism, and granular basophilic cytoplasm | |||
* Arranged in cell nests | |||
* Stippled chromatin | |||
* Highly vascular | |||
* VHL, RET, NF1SDHB and SDHD gene mutation | * VHL, RET, NF1SDHB and SDHD gene mutation | ||
Revision as of 16:58, 9 November 2015
- 40-50 yo patients
- May have refractory hypertension, palpitations, headache, diaphoresis, anxiety, weight loss, and flank pain
- MEN, von Hippel–Lindau disease, tuberous sclerosis, or neurofibromatosis
- Pallor
- Tachycardia
- Elevated serum catecholamines and metanephrines
- Large, heterogeneous mass on CT
- Areas of necrosis and cystic change
- on CT
- Polygonal cells, nuclear pleomorphism, and granular basophilic cytoplasm
- Arranged in cell nests
- Stippled chromatin
- Highly vascular
- VHL, RET, NF1SDHB and SDHD gene mutation
Nonmalignant causes
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying