Sandbox: DDx Kidney mass: Difference between revisions

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* 40-50 yo patients
Asymptomatic
* May have refractory hypertension, palpitations, headache, diaphoresis, anxiety,  weight loss, and flank pain
Incidental finding on imaging
* MEN, von Hippel–Lindau disease, tuberous sclerosis, or neurofibromatosis
May have hematuria and flank pain
 
Palpable flank mass
* Pallor
* Tachycardia
 
* Elevated serum catecholamines and metanephrines
 
* Large, heterogeneous mass on CT
* Areas of necrosis and cystic change
*  on CT
 
* Polygonal cells, nuclear pleomorphism, and granular basophilic cytoplasm
* Arranged in cell nests
* Stippled chromatin
* Highly vascular
 
 
 
* VHL, RET, NF1SDHB and SDHD gene mutation


==Nonmalignant causes==
==Nonmalignant causes==
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying
anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

Revision as of 19:43, 9 November 2015

Asymptomatic Incidental finding on imaging May have hematuria and flank pain Palpable flank mass

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying

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