Waldenström's macroglobulinemia differential diagnosis: Difference between revisions
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{{Waldenström's macroglobulinemia}} | {{Waldenström's macroglobulinemia}} | ||
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including: | Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including: | ||
*Chronic lymphocytic leukemia/small lymphocytic lymphoma: | *Chronic lymphocytic leukemia/small lymphocytic lymphoma: | ||
::*Always express CD5, usually CD23 positive | ::*Always express CD5, usually CD23 positive<ref name="UTD">Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015</ref> | ||
*B-cell prolymphocytic leukemia: | *B-cell prolymphocytic leukemia: | ||
::*Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7) | ::*Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)<ref name="UTD"></ref> | ||
*Follicular lymphoma: | *Follicular lymphoma: | ||
::*Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA | ::*Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA<ref name="UTD"></ref> | ||
::*Bone marrow infiltration of small, cleaved cells that are usually paratrabecular<ref name="pubM">{{cite journal |vauthors=Sahin I, Leblebjian H, Treon SP, Ghobrial IM |title=Waldenström macroglobulinemia: from biology to treatment |journal=Expert Rev Hematol |volume=7 |issue=1 |pages=157–68 |year=2014 |pmid=24405328 |doi=10.1586/17474086.2014.871494 |url=}}</ref> | |||
::*Rearrangement of Bcl-2 | |||
*Multiple myeloma: | *Multiple myeloma: | ||
::*Express CD138, CD38, CD79a, and VS38c and CD56(70%) | ::*Express CD138, CD38, CD79a, and VS38c and CD56(70%)<ref name="UTD"></ref> | ||
::*Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency<ref name="pubM"></ref> | |||
::*Translocation involving chromosome 11 (t 11;14) | |||
*Mantle cell lymphoma: | *Mantle cell lymphoma: | ||
::* Express CD5+ and CD23-, surface IgM and IgD and cyclin D1 in majority of cases | ::* Express CD5+ and CD23-, surface IgM and IgD and cyclin D1 in majority of cases<ref name="UTD"></ref> | ||
::*Infiltration of bone marrow by monomorphous, small lymphoid cells with irregular nuclei<ref name="pubM"></ref> | |||
*Marginal zone lymphoma: | *Marginal zone lymphoma: | ||
::*Expresses B cell markers CD19, CD20, and CD22 | ::*Expresses B cell markers CD19, CD20, and CD22<ref name="UTD"></ref> | ||
::*Infiltrates the bone marrow with a characteristic intertrabecular and intrasinusoidal pattern<ref name="pubM"></ref> | |||
::*Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% ) | |||
Revision as of 20:44, 9 November 2015
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Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:
- Chronic lymphocytic leukemia/small lymphocytic lymphoma:
- Always express CD5, usually CD23 positive[1]
- B-cell prolymphocytic leukemia:
- Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)[1]
- Follicular lymphoma:
- Multiple myeloma:
- Mantle cell lymphoma:
- Marginal zone lymphoma:
References=
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
- ↑ 2.0 2.1 2.2 2.3 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.