Metanephric adenoma overview: Difference between revisions
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Metanephric adenoma may be caused by the allelic changes of [[tumor suppressor gene]] on [[chromosome]] 2p13. | Metanephric adenoma may be caused by the allelic changes of [[tumor suppressor gene]] on [[chromosome]] 2p13. | ||
<ref name="pmid11172302">{{cite journal |vauthors=Pesti T, Sükösd F, Jones EC, Kovacs G |title=Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping |journal=[[Human Pathology]] |volume=32 |issue=1 |pages=101–4 |year=2001 |pmid=11172302 |doi=10.1053/hupa.2001.21132 |url=http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(01)63640-2 |issn=}}</ref> | <ref name="pmid11172302">{{cite journal |vauthors=Pesti T, Sükösd F, Jones EC, Kovacs G |title=Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping |journal=[[Human Pathology]] |volume=32 |issue=1 |pages=101–4 |year=2001 |pmid=11172302 |doi=10.1053/hupa.2001.21132 |url=http://linkinghub.elsevier.com/retrieve/pii/S0046-8177(01)63640-2 |issn=}}</ref> | ||
==Differential Diagnosis== | |||
Metanephric adenoma must be differentiated from [[renal cell carcinoma]] and [[Wilm's tumor]].<ref name="pmid17640685">{{cite journal |vauthors=Hartman DJ, Maclennan GT |title=Renal metanephric adenoma |journal=[[The Journal of Urology]] |volume=178 |issue=3 Pt 1 |pages=1058 |year=2007 |pmid=17640685 |doi=10.1016/j.juro.2007.06.002 |url=http://linkinghub.elsevier.com/retrieve/pii/S0022-5347(07)01560-1 |issn=}}</ref> | |||
==Epidemiology and Demographics== | |||
The [[incidence]] of metanephric adenoma increases with age; the median age at diagnosis is 50-60 years.<ref name="pmid18094306">{{cite journal |vauthors=Prasad SR, Surabhi VR, Menias CO, Raut AA, Chintapalli KN |title=Benign renal neoplasms in adults: cross-sectional imaging findings |journal=[[AJR. American Journal of Roentgenology]] |volume=190 |issue=1 |pages=158–64 |year=2008 |pmid=18094306 |doi=10.2214/AJR.07.2724 |url=http://www.ajronline.org/doi/abs/10.2214/AJR.07.2724 |issn=}}</ref> Females are more commonly affected with metanephric adenoma than males. The female to male ratio is approximately 2 to 1.<ref name="pmid18094306">{{cite journal |vauthors=Prasad SR, Surabhi VR, Menias CO, Raut AA, Chintapalli KN |title=Benign renal neoplasms in adults: cross-sectional imaging findings |journal=[[AJR. American Journal of Roentgenology]] |volume=190 |issue=1 |pages=158–64 |year=2008 |pmid=18094306 |doi=10.2214/AJR.07.2724 |url=http://www.ajronline.org/doi/abs/10.2214/AJR.07.2724 |issn=}}</ref> | |||
==Risk Factors== | |||
There are no established risk factors for metanephric adenoma. | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Metanephric adenoma (MA)is a rare, benign tumor of the kidney.
Historical Perspective
Metanephric adenoma was first described by Brisigotti, Cozzutto et al. in 1992.[1]
Classification
There is no classification system established for metanephric adenoma.
Pathophysiology
On gross pathology, a sharply circumscribed, nonencapsulated solitary mass is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine chromatin and smooth nuclear membrane, variable architecture, and psammoma bodies are characteristic findings of metanephric adenoma.
Causes
Metanephric adenoma may be caused by the allelic changes of tumor suppressor gene on chromosome 2p13. [2]
Differential Diagnosis
Metanephric adenoma must be differentiated from renal cell carcinoma and Wilm's tumor.[3]
Epidemiology and Demographics
The incidence of metanephric adenoma increases with age; the median age at diagnosis is 50-60 years.[4] Females are more commonly affected with metanephric adenoma than males. The female to male ratio is approximately 2 to 1.[4]
Risk Factors
There are no established risk factors for metanephric adenoma.
References
- ↑ Brisigotti M, Cozzutto C, Fabbretti G, Sergi C, Callea F (1992). "Metanephric adenoma". Histology and Histopathology. 7 (4): 689–92. PMID 1333853.
- ↑ Pesti T, Sükösd F, Jones EC, Kovacs G (2001). "Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping". Human Pathology. 32 (1): 101–4. doi:10.1053/hupa.2001.21132. PMID 11172302.
- ↑ Hartman DJ, Maclennan GT (2007). "Renal metanephric adenoma". The Journal of Urology. 178 (3 Pt 1): 1058. doi:10.1016/j.juro.2007.06.002. PMID 17640685.
- ↑ 4.0 4.1 Prasad SR, Surabhi VR, Menias CO, Raut AA, Chintapalli KN (2008). "Benign renal neoplasms in adults: cross-sectional imaging findings". AJR. American Journal of Roentgenology. 190 (1): 158–64. doi:10.2214/AJR.07.2724. PMID 18094306.