Neurofibroma overview: Difference between revisions
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==Overview== | ==Overview== | ||
''' | A '''neurofibroma''' is a benign [[nerve sheath tumor]] in the [[peripheral nervous system]]. Usually found in persons with [[neurofibromatosis type I]] (NF1), an [[Genetic disorder#Autosomal dominant|autosomal dominant]] [[genetic disorder|genetically inherited disease]], they can result in a range of symptoms from physical disfiguration and pain to cognitive disability. Neurofibromas arise from nonmyelinating-type [[Schwann cells]] that exhibit [[Allele|biallelic inactivation]] of the NF1 gene that codes for the protein [[Neurofibromin 1|neurofibromin]].<ref name="pmid11159187">{{cite journal |author=Muir D, Neubauer D, Lim IT, Yachnis AT, Wallace MR. |title=Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells. |journal= American Journal of Pathology |volume=158 |issue=2 |pages=501–13 |year=2003 |pmid=11159187 |doi= 10.1016/S0002-9440(10)63992-2|pmc=1850316}}</ref> This protein is responsible for regulating the [[Ras (protein)|RAS]]-mediated [[cell growth]] [[signaling pathway]]. In contrast to [[schwannomas]], another type of tumor arising from Schwann cells, neurofibromas incorporate many additional types of cells and structural elements in addition to Schwann cells, making it difficult to identify and understand all the mechanisms through which they originate and develop.<ref>{{cite web |author=Miller RT |title=Immunohistochemistry in the differential diagnosis of schwannoma and neurofibroma |date=October 2004 |work=Propath |publisher= |url=http://www.ihcworld.com/_newsletter/2004/2004-10_NF_vs_schwannoma_v1.pdf |format=PDF}}</ref> | ||
==References== | ==References== | ||
Revision as of 20:02, 12 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
A neurofibroma is a benign nerve sheath tumor in the peripheral nervous system. Usually found in persons with neurofibromatosis type I (NF1), an autosomal dominant genetically inherited disease, they can result in a range of symptoms from physical disfiguration and pain to cognitive disability. Neurofibromas arise from nonmyelinating-type Schwann cells that exhibit biallelic inactivation of the NF1 gene that codes for the protein neurofibromin.[1] This protein is responsible for regulating the RAS-mediated cell growth signaling pathway. In contrast to schwannomas, another type of tumor arising from Schwann cells, neurofibromas incorporate many additional types of cells and structural elements in addition to Schwann cells, making it difficult to identify and understand all the mechanisms through which they originate and develop.[2]
References
- ↑ Muir D, Neubauer D, Lim IT, Yachnis AT, Wallace MR. (2003). "Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells". American Journal of Pathology. 158 (2): 501–13. doi:10.1016/S0002-9440(10)63992-2. PMC 1850316. PMID 11159187.
- ↑ Miller RT (October 2004). "Immunohistochemistry in the differential diagnosis of schwannoma and neurofibroma" (PDF). Propath.