Myelofibrosis causes: Difference between revisions

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Revision as of 18:30, 12 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Myelofibrosis is caused by a mutation in JAK2, CALR, and MPL genes.^[1]^[2]^[3]

Myelofibrosis is caused by a mutation in the following genes: ^[1]^[2]^[3]

↑ ^1.0 ^1.1 Tefferi, A; Lasho, T L; Finke, C M; Knudson, R A; Ketterling, R; Hanson, C H; Maffioli, M; Caramazza, D; Passamonti, F; Pardanani, A (2014). "CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons". Leukemia. 28 (7): 1472–1477. doi:10.1038/leu.2014.3. ISSN 0887-6924.
↑ ^2.0 ^2.1 Baxter EJ, Scott LM, Campbell PJ; et al. (2005). "Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders". Lancet. 365 (9464): 1054–61. doi:10.1016/S0140-6736(05)71142-9. PMID 15781101.
↑ ^3.0 ^3.1 Pikman Y, Lee BH, Mercher T; et al. (2006). "MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia". PLoS Med. 3 (7): e270. doi:10.1371/journal.pmed.0030270. PMC 1502153. PMID 16834459. Unknown parameter |month= ignored (help)

@@ Line 10: / Line 10: @@
 *''[[Calreticulin|CALR]]''
 *''[[Myeloproliferative leukemia virus oncogene|MPL]]''
-*Bone marrow is the soft, fatty tissue inside bones, responsible for hematopoiesis. Stem cells are immature cells in the bone marrow that give rise to all of your blood cells. Blood is made of:
-:*Red blood cells (which carry oxygen to tissues)
-:*White blood cells (which fight infections)
-:*Platelets (which help blood clot)
-*Scarring of the bone marrow means the marrow is not able to make enough blood cells. Anemia, bleeding tendency, and a higher risk of infections may occur.
-*As a result, the liver and spleen make some of these blood cells. This causes these organs to swell, which is called extramedullary hematopoiesis.
-*The cause of myelofibrosis is unknown. There are no known risk factors. The disorder usually develops slowly in people over age 50.
-*Diseases such as leukemia and lymphoma may also cause bone marrow scarring. This is called secondary myelofibrosis.
 ==References==