Neurofibroma classification: Difference between revisions

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Revision as of 19:35, 13 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Neurofibroma may be classified into 2 subtypes: dermal neurofibroma and plexiform neurofibroma.

Classification

Neurofibroma may be classified into 2 subtypes:^[1]

Dermal neurofibroma

Dermal neurofibromas are associated with a single peripheral nerve.

Plexiform Neurofibroma

Plexiform neurofibromas are associated with multiple nerve bundles.

References

↑ Neurofibroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Neurofibroma

Template:WikiDoc Sources

[1] Neurofibroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Neurofibroma

[1]

@@ Line 3: / Line 3: @@
 {{CMG}}; {{AE}} {{SC}}
 ==Overview==
+Neurofibroma may be classified into 2 subtypes: dermal neurofibroma and plexiform neurofibroma.
 ==Classification==
-Neurofibromas have been subdivided into two broad categories: dermal and plexiform.  Dermal neurofibromas are associated with a single peripheral nerve, while plexiform neurofibromas are associated with multiple nerve bundles.  According to the World Health Organization classification system, dermal and plexiform neurofibromas are [[Grading (tumors)|grade I]] tumors.  Plexiform neurofibroma are more difficult to treat and can transform into malignant tumors.  Dermal neurofibroma do not become malignant.
+Neurofibroma may be classified into 2 subtypes:<ref>Neurofibroma. Wikipedia 2015. https://en.wikipedia.org/wiki/Neurofibroma</ref>
+* Dermal neurofibroma
-===Dermal neurofibroma===
+:* Dermal neurofibromas are associated with a single peripheral nerve.
+* Plexiform Neurofibroma
-===Plexiform Neurofibroma===
+:* Plexiform neurofibromas are associated with multiple nerve bundles.
-About 10% of plexiform neurofibromas undergo transformation into a [[malignant peripheral nerve sheath tumor]] (MPNST).<ref name="pmid12898075">{{cite journal |author=Mautner VF, Friedrich RE, von Deimling A, Hagel C, Korf B, Knöfel MT, Wenzel R, Fünsterer C. |title=Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma. |journal=American Journal of Pathology |volume=45 |issue=9 |pages=618–25 |year=2003 |pmid=12898075 |doi=10.1007/s00234-003-0964-6}}</ref>  The formation of malignant cancers from neurofibromas is associated with the loss of expression of the [[P16 (gene)|CDKN2A]] or [[TP53]] gene in non-myelinating Schwann cells that also exhibit biallelic inactivation of the NF1 gene.
 ==References==

Neurofibroma classification: Difference between revisions

Revision as of 19:35, 13 November 2015

Overview

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