Essential thrombocytosis laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of essential thrombocytosis include abnormal [[complete blood count]] ([[CBC]]), elevated platelet count, peripheral blood smear showing large platelets, megakaryocyte fragments and platelet aggregates, presence of ''[[JAK2]]'' mutation and absence of ''BCR-ABL'' or [[Philadelphia chromosome]].<ref>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> [[Leukocytosis]], [[erythrocytosis]], and mild [[anemia]] may be present. Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis as per WHO definition.<ref name="pmidhttp://dx.doi.org/10.1182/blood-2007-04-083501">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2007-04-083501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | Laboratory findings consistent with the diagnosis of essential thrombocytosis include abnormal [[complete blood count]] ([[CBC]]), elevated platelet count, peripheral blood smear showing large platelets, megakaryocyte fragments and platelet aggregates, presence of ''[[JAK2]]'' mutation and absence of ''BCR-ABL'' or [[Philadelphia chromosome]].<ref name=re>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> [[Leukocytosis]], [[erythrocytosis]], and mild [[anemia]] may be present. Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis as per WHO definition.<ref name="pmidhttp://dx.doi.org/10.1182/blood-2007-04-083501">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=http://dx.doi.org/10.1182/blood-2007-04-083501 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10 }} </ref> | ||
==Laboratory findings== | ==Laboratory findings== | ||
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**Elevated platelet count | **Elevated platelet count | ||
**[[Leukocytosis]], [[erythrocytosis]], and mild anemia may be present | **[[Leukocytosis]], [[erythrocytosis]], and mild anemia may be present | ||
*Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates<ref>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> | *Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates<ref name=re>Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.</ref> | ||
*To rule out inflammatory disorders | *To rule out inflammatory disorders | ||
**Erythrocyte sedimentation rate ([[ESR]]) | **Erythrocyte sedimentation rate ([[ESR]]) | ||
Revision as of 14:56, 17 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Laboratory findings consistent with the diagnosis of essential thrombocytosis include abnormal complete blood count (CBC), elevated platelet count, peripheral blood smear showing large platelets, megakaryocyte fragments and platelet aggregates, presence of JAK2 mutation and absence of BCR-ABL or Philadelphia chromosome.[1] Leukocytosis, erythrocytosis, and mild anemia may be present. Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis as per WHO definition.[2]
Laboratory findings
Essential thrombocytosis remains a diagnosis of exclusion that needs to rule out reactive or secondary causes of thrombocytosis . Laboratory tests for the diagnosis of essential thrombocytosis include the following[3]:
- Complete blood count (CBC)
- Elevated platelet count
- Leukocytosis, erythrocytosis, and mild anemia may be present
- Peripheral blood smear shows large platelets, megakaryocyte fragments and platelet aggregates[1]
- To rule out inflammatory disorders
- Erythrocyte sedimentation rate (ESR)
- C-reactive protein (CRP)
- Fibrinogen
- To rule out iron deficiency and polycythemia vera
- Serum ferritin
- Hematocrit
- To rule out other myeloproliferative neoplasms
- BCR-ABL or Philadelphia chromosome
- Genetic studies
- JAK2 mutation using PCR
References
- ↑ 1.0 1.1 Essential Thrombocythemia. Merck manual. http://www.merckmanuals.com/professional/hematology-and-oncology/myeloproliferative-disorders/essential-thrombocythemia. Accessed on November 11,2015.
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID http://dx.doi.org/10.1182/blood-2007-04-083501 Check
|pmid=value (help). - ↑ Essential Thrombocytosis Workup. Medscape. http://emedicine.medscape.com/article/206697-workup#c8. Accessed on November 10th, 2015