Ovarian germ cell tumor pathophysiology: Difference between revisions

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Revision as of 15:30, 17 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

The pathophysiology of ovarian germ cell tumor depends on the histological subtype.^[1]

Ovarian germ cell tumor subtype	Features on Gross Pathology
Dysgerminoma	External surface is smooth and bosselated (knobby) Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
Endodermal sinus tumor or yolk sac tumors	External surface is smooth and glistening^[2] Cut surface is cystic with hemorrhage and necrosis
Embryonal Carcinoma	A poorly defined, pale grey tumor with associated haemorrhage and necrosis.^[1]
Teratoma	Teratoma-mature Solid or cystic^[3] Cystic content may contain greasy material composed of keratin, hair and teeth Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair Teratoma-immature Bulky, solid or cystic with necrosis, hemorrhage^[4]

Ovarian germ cell tumor subtype	Features on Histopathological Microscopic Analysis	Image
Dysgerminomas	Uniform cells that resemble primordial germ cells The stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas	Micrograph a seminoma, a tumor that is histologically indistinguishable from dysgerminoma.
Endodermal sinus tumor or yolk sac tumors	Schiller-Duval bodies - key feature	Micrograph showing the yolk sac component of a mixed germ cell tumor.
Embryonal carcinoma	Main features:^[1] Nuclear atypia Nucleoli prominent Necrosis common Nuclei overlap Other features: Variable architecture: Tubulopapillary Glandular Solid Embryoid bodies - ball of cells in surrounded by empty space on three sides Mitoses common	Embryonal carcinoma
Teratoma	Mature teratoma The sections show ovarian parenchyma with a lesion consisting of benign dermal, gastrointestinal and neural elements The neural elements show focal degenerative changes with macrophages, and giant cells Siderophages are present	Teratoma

↑ ^1.0 ^1.1 ^1.2 Abbas, Fausto, Mitchell (2010). Basic Pathology. Elsevier. pp. 696–697. ISBN 978-81-312-1036-9.
↑ Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015
↑ Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015
↑ Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015

@@ Line 16: / Line 16: @@
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 |Endodermal sinus tumor or yolk sac tumors||
-* External surface is smooth and glistening
+* External surface is smooth and glistening<ref> Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
 * Cut surface is cystic with hemorrhage and necrosis
 |-
@@ Line 24: / Line 24: @@
 | Teratoma||
 Teratoma-mature
-* Solid or cystic
+* Solid or cystic<ref> Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
 * Cystic content may contain greasy material composed of keratin, hair and teeth
 * Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair
 Teratoma-immature
-* Bulky, solid or cystic with necrosis, hemorrhage <ref> Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
+* Bulky, solid or cystic with necrosis, hemorrhage<ref> Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015</ref>
 |-
 |}