Ovarian germ cell tumor pathophysiology: Difference between revisions

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| Dysgerminoma||
| Dysgerminoma||
* External surface is smooth and bosselated (knobby)
* External surface is smooth and bosselated (knobby)<ref name= www> Ovary tumor Germ cell tumors Yolk sac tumor. http://www.pathologyoutlines.com/topic/ovarytumoryolksac.html. URL Accessed on November 12, 2015</ref>
* Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
* Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
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|Endodermal sinus tumor or yolk sac tumors||
|Endodermal sinus tumor or yolk sac tumors||
* External surface is smooth and glistening<ref> Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
* External surface is smooth and glistening<ref name= www> Ovary tumor Germ cell tumors Yolk sac tumor. http://www.pathologyoutlines.com/topic/ovarytumoryolksac.html. URL Accessed on November 12, 2015</ref>
* Cut surface is cystic with hemorrhage and necrosis
* Cut surface is cystic with hemorrhage and necrosis
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| Teratoma||
| Teratoma||
Teratoma-mature
Teratoma-mature
* Solid or cystic<ref> Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
* Solid or cystic<ref name= aaa> Ovary tumor Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015</ref>
* Cystic content may contain greasy material composed of keratin, hair and teeth
* Cystic content may contain greasy material composed of keratin, hair and teeth
* Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair
* Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair
Teratoma-immature
Teratoma-immature
* Bulky, solid or cystic with necrosis, hemorrhage<ref> Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015</ref>
* Bulky, solid or cystic with necrosis, hemorrhage<ref name= abc> Ovary tumor Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015</ref>
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Revision as of 15:33, 17 November 2015

Ovarian germ cell tumor Microchapters

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Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology and Demographics

Risk Factors

Screening

Differentiating Ovarian germ cell tumor from other Diseases

Natural History, Complications and Prognosis

Diagnosis

Staging

Diagnostic Study of Choice

History and Symptoms

Physical Examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

Overveiw

The pathophysiology of ovarian germ cell tumor depends on the histological subtype.[1]


Gross Patholgy

Ovarian germ cell tumor subtype Features on Gross Pathology
Dysgerminoma
  • External surface is smooth and bosselated (knobby)[2]
  • Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
Endodermal sinus tumor or yolk sac tumors
  • External surface is smooth and glistening[2]
  • Cut surface is cystic with hemorrhage and necrosis
Embryonal Carcinoma
Teratoma

Teratoma-mature

  • Solid or cystic[3]
  • Cystic content may contain greasy material composed of keratin, hair and teeth
  • Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair

Teratoma-immature

  • Bulky, solid or cystic with necrosis, hemorrhage[4]

Microscopic Pathology

Ovarian germ cell tumor subtype Features on Histopathological Microscopic Analysis Image
Dysgerminomas
  • Uniform cells that resemble primordial germ cells
  • The stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas
Micrograph a seminoma, a tumor that is histologically indistinguishable from dysgerminoma.
Endodermal sinus tumor or yolk sac tumors
  • Schiller-Duval bodies - key feature
Micrograph showing the yolk sac component of a mixed germ cell tumor.


Embryonal carcinoma

Main features:[1]

  • Nuclear atypia
  • Nucleoli prominent
  • Necrosis common
  • Nuclei overlap

Other features:

  • Variable architecture:
  • Tubulopapillary
  • Glandular
  • Solid
  • Embryoid bodies - ball of cells in surrounded by empty space on three sides
  • Mitoses common
Embryonal carcinoma
Teratoma

Mature teratoma

  • The sections show ovarian parenchyma with a lesion consisting of benign dermal, gastrointestinal and neural elements
  • The neural elements show focal degenerative changes with macrophages, and giant cells
  • Siderophages are present
Teratoma

References

  1. ↑ 1.0 1.1 1.2 Abbas, Fausto, Mitchell (2010). Basic Pathology. Elsevier. pp. 696–697. ISBN 978-81-312-1036-9.
  2. ↑ 2.0 2.1 Ovary tumor Germ cell tumors Yolk sac tumor. http://www.pathologyoutlines.com/topic/ovarytumoryolksac.html. URL Accessed on November 12, 2015
  3. ↑ Ovary tumor Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015
  4. ↑ Ovary tumor Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015

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