Ovarian germ cell tumor pathophysiology: Difference between revisions

	Ovarian germ cell tumor Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Epidemiology and Demographics
Risk Factors
Screening
Differentiating Ovarian germ cell tumor from other Diseases
Natural History, Complications and Prognosis
Diagnosis
Staging
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Surgery
Chemotherapy
Radiotherapy
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Ovarian germ cell tumor pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Ovarian germ cell tumor pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Ovarian germ cell tumor pathophysiology
CDC on Ovarian germ cell tumor pathophysiology
Ovarian germ cell tumor pathophysiology in the news
Blogs on Ovarian germ cell tumor pathophysiology
Directions to Hospitals Treating Ovarian germ cell tumor
Risk calculators and risk factors for Ovarian germ cell tumor pathophysiology

Revision as of 15:58, 17 November 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]

The pathophysiology of ovarian germ cell tumor depends on the histological subtype.^[1]

Ovarian germ cell tumor subtype	Features on Gross Pathology
Dysgerminoma	External surface is smooth and bosselated (knobby)^[2] Cut surface it is soft, fleshy and either cream-coloured, gray, pink or tan
Endodermal sinus tumor or yolk sac tumors	External surface is smooth and glistening^[3] Cut surface is cystic with hemorrhage and necrosis
Embryonal Carcinoma	A poorly defined, pale grey tumor with associated haemorrhage and necrosis.^[1]
Teratoma	Teratoma-mature Solid or cystic^[4] Cystic content may contain greasy material composed of keratin, hair and teeth Teeth may be found in Rokitansky’s protuberance - a well-defined, nipple-like structure covered with hair Teratoma-immature Bulky, solid or cystic with necrosis, hemorrhage^[5]

Ovarian germ cell tumor subtype	Features on Histopathological Microscopic Analysis	Image
Dysgerminomas	Uniform cells that resemble primordial germ cells ^[2] The stroma contains lymphocytes and about 20% of patients have sarcoid-like granulomas	Micrograph a seminoma, a tumor that is histologically indistinguishable from dysgerminoma.
Endodermal sinus tumor or yolk sac tumors	Schiller-Duval bodies - key feature^[6]	Micrograph showing the yolk sac component of a mixed germ cell tumor.
Embryonal carcinoma	Main features:^[1] Nuclear atypia Nucleoli prominent Necrosis common Nuclei overlap Other features: Variable architecture: Tubulopapillary Glandular Solid Embryoid bodies - ball of cells in surrounded by empty space on three sides Mitoses common	Embryonal carcinoma
Teratoma	Mature teratoma The sections show ovarian parenchyma with a lesion consisting of benign dermal, gastrointestinal and neural elements ^[7] The neural elements show focal degenerative changes with macrophages, and giant cells Siderophages are present	Teratoma

↑ ^1.0 ^1.1 ^1.2 Abbas, Fausto, Mitchell (2010). Basic Pathology. Elsevier. pp. 696–697. ISBN 978-81-312-1036-9.
↑ ^2.0 ^2.1 Dysgerminoma. https://en.wikipedia.org/wiki/Dysgerminoma. URL Accessed on November 12, 2015
↑ Ovary tumor Germ cell tumors Yolk sac tumor. http://www.pathologyoutlines.com/topic/ovarytumoryolksac.html. URL Accessed on November 12, 2015
↑ Ovary tumor Germ cell tumors Teratoma-mature. http://www.pathologyoutlines.com/topic/ovarytumorteratomamature.html. URL Accessed on November 12, 2015
↑ Ovary tumor Germ cell tumors Teratoma-immature. http://www.pathologyoutlines.com/topic/ovarytumorteratomaimmature.html. URL Accessed on November 12, 2015
↑ Endodermal sinus tumor. https://en.wikipedia.org/wiki/Endodermal_sinus_tumor. URL Accessed on November 12, 2015
↑ Mature teratoma. http://librepathology.org/wiki/index.php/Teratoma#Mature_teratoma. URL Accessed on November 12, 2015

@@ Line 4: / Line 4: @@
 ==Overveiw==
 The pathophysiology of ovarian germ cell tumor depends on the histological subtype.<ref name=Robbins>{{cite book|last=Abbas, Fausto, Mitchell|title=Basic Pathology|year=2010|publisher=Elsevier|isbn=978-81-312-1036-9|pages=696–697}}</ref>
 ==Gross Patholgy==
@@ Line 46: / Line 45: @@
 |-
 |Endodermal sinus tumor or yolk sac tumors||
-* Schiller-Duval bodies - key feature
+* Schiller-Duval bodies - key feature<ref name= wrr> Endodermal sinus tumor. https://en.wikipedia.org/wiki/Endodermal_sinus_tumor. URL Accessed on November 12, 2015</ref>
 | [[Image:800px-Mixed_germ_cell_tumour_-_high_mag.jpg|thumb|none|300px|Micrograph showing the yolk sac component of a mixed germ cell tumor.]]