Tongue cancer pathophysiology: Difference between revisions
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On gross pathology, exophytic, ulcerative, and infiltarative growth patterns are characteristic findings of tongue cancer. | On gross pathology, exophytic, ulcerative, and infiltarative growth patterns are characteristic findings of tongue cancer. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The mutations in tumor suppressor genes has been reported in patients with tongue cancer. Genes involved in the pathogenesis of tongue cancer include TP53, which is located on chromosome 17. Other oncogenes associated with squamous cell cancers of the tongue include ''c-myc'' and ''erb -b1''. | The mutations in tumor suppressor genes has been reported in patients with tongue cancer. Genes involved in the pathogenesis of tongue cancer include ''TP53'', which is located on chromosome 17. Other oncogenes associated with squamous cell cancers of the tongue include ''c-myc'' and ''erb -b1''. | ||
Squamous cell carcinoma is the most common malignancy of the tongue. It typically has three gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. | Squamous cell carcinoma is the most common malignancy of the tongue. It typically has three gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. | ||
The infiltrative and ulcerative are the types most commonly observed on the tongue. | The infiltrative and ulcerative are the types most commonly observed on the tongue. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 21:22, 17 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Genes involved in the pathogenesis of tongue cancer include TP53, c-myc, and erb-b1. On gross pathology, exophytic, ulcerative, and infiltarative growth patterns are characteristic findings of tongue cancer.
Pathophysiology
The mutations in tumor suppressor genes has been reported in patients with tongue cancer. Genes involved in the pathogenesis of tongue cancer include TP53, which is located on chromosome 17. Other oncogenes associated with squamous cell cancers of the tongue include c-myc and erb -b1. Squamous cell carcinoma is the most common malignancy of the tongue. It typically has three gross morphologic growth patterns: exophytic, ulcerative, and infiltrative. The infiltrative and ulcerative are the types most commonly observed on the tongue.