Waldenström's macroglobulinemia differential diagnosis: Difference between revisions
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Waldenström's macroglobulinemia must be differentiated from [[multiple myeloma]], [[chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], [[b-cell prolymphocytic leukemia]], [[follicular lymphoma]], [[mantle cell lymphoma]], and marginal zone lymphoma.<ref name="UTD">Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015</ref><ref name="pubM">{{cite journal |vauthors=Sahin I, Leblebjian H, Treon SP, Ghobrial IM |title=Waldenström macroglobulinemia: from biology to treatment |journal=Expert Rev Hematol |volume=7 |issue=1 |pages=157–68 |year=2014 |pmid=24405328 |doi=10.1586/17474086.2014.871494 |url=}}</ref> | Waldenström's macroglobulinemia must be differentiated from [[multiple myeloma]], [[chronic lymphocytic leukemia]]/[[small lymphocytic lymphoma]], [[b-cell prolymphocytic leukemia]], [[follicular lymphoma]], [[mantle cell lymphoma]], and marginal zone lymphoma.<ref name="UTD">Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015</ref><ref name="pubM">{{cite journal |vauthors=Sahin I, Leblebjian H, Treon SP, Ghobrial IM |title=Waldenström macroglobulinemia: from biology to treatment |journal=Expert Rev Hematol |volume=7 |issue=1 |pages=157–68 |year=2014 |pmid=24405328 |doi=10.1586/17474086.2014.871494 |url=}}</ref> | ||
==Differentiating Waldenström's Macroglobulinemia | ==Differentiating Waldenström's Macroglobulinemia from other B Cell Lymphoid Neoplasms== | ||
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:<ref name="UTD">Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015</ref><ref name="pubM">{{cite journal |vauthors=Sahin I, Leblebjian H, Treon SP, Ghobrial IM |title=Waldenström macroglobulinemia: from biology to treatment |journal=Expert Rev Hematol |volume=7 |issue=1 |pages=157–68 |year=2014 |pmid=24405328 |doi=10.1586/17474086.2014.871494 |url=}}</ref> | Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:<ref name="UTD">Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015</ref><ref name="pubM">{{cite journal |vauthors=Sahin I, Leblebjian H, Treon SP, Ghobrial IM |title=Waldenström macroglobulinemia: from biology to treatment |journal=Expert Rev Hematol |volume=7 |issue=1 |pages=157–68 |year=2014 |pmid=24405328 |doi=10.1586/17474086.2014.871494 |url=}}</ref> | ||
Revision as of 18:38, 18 November 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
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Overview
Waldenström's macroglobulinemia must be differentiated from multiple myeloma, chronic lymphocytic leukemia/small lymphocytic lymphoma, b-cell prolymphocytic leukemia, follicular lymphoma, mantle cell lymphoma, and marginal zone lymphoma.[1][2]
Differentiating Waldenström's Macroglobulinemia from other B Cell Lymphoid Neoplasms
Waldenström's macroglobulinemia must be differentiated from other B cell lymphoid neoplasms including:[1][2]
- Always express CD5, usually CD23 positive
- Express bright surface IgM, CD20 and other B-cell antigens (CD19, CD22, CD79a, FMC7)
- Express CD10, HLA-DR, pan B-cell antigens (CD19, CD20, CD79a), CD21, and surface IgM, IgG, or IgA
- Bone marrow infiltration of small, cleaved cells that are usually paratrabecular
- Rearrangement of Bcl-2
- Express CD138, CD38, CD79a, VS38c and CD56(70%)
- Presence of Plasmacytic cell infiltration of bone marrow, osteolytic lesions and renal insufficiency
- Translocation involving chromosome 11 (t11;14)
- Express CD5+ and CD23-; surface IgM, IgD and cyclin D1 in majority of cases
- Infiltration of bone marrow by monomorphous, small lymphoid cells with irregular nuclei
- Marginal zone lymphoma:
- Expresses B cell markers CD19, CD20, and CD22
- Infiltrates the bone marrow with a characteristic intertrabecular and intrasinusoidal pattern
- Most common cytogenetic abnormalities are loss of 7q (19%) along with +3q (19%) and +5q (10% )
References
- ↑ 1.0 1.1 Clinical manifestations, pathologic features, and diagnosis of lymphoplasmacytic lymphoma. UpToDate (2015)http://www.uptodate.com/contents/clinical-manifestations-pathologic-features-and-diagnosis-of-lymphoplasmacytic-lymphoma?source=see_link§ionName=PATHOGENESIS&anchor=H198194648#H198194648 Accessed on November 9, 2015
- ↑ 2.0 2.1 Sahin I, Leblebjian H, Treon SP, Ghobrial IM (2014). "Waldenström macroglobulinemia: from biology to treatment". Expert Rev Hematol. 7 (1): 157–68. doi:10.1586/17474086.2014.871494. PMID 24405328.