Linitis plastica pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
On gross pathology, thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the tumor cells are characteristic findings of linitis plastica.<ref>Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.</ref> On microscopic histopathological analysis, atypical [[signet ring cell]]s diffusely infiltrating the stomach wall, submucosal fibrosis and thickening, with minimal [[mucosa]]l involvement are characteristic findings of linitis plastica.<ref name="SchauerPeiper2011">{{cite journal|last1=Schauer|first1=M|last2=Peiper|first2=M|last3=Theisen|first3=J|last4=Knoefel|first4=W|title=Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment|journal=European Journal of Medical Research|volume=16|issue=1|year=2011|pages=29|issn=2047-783X|doi=10.1186/2047-783X-16-1-29}}</ref> As a result of the infiltration and fibrosis there is diffuse thickening and rigidity of the gastric wall making the process of digestion difficult. Mucosa is usually spared and rarely show superficial ulcerations on endoscopy that has a wide differential | *On gross pathology, thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the tumor cells are characteristic findings of linitis plastica.<ref>Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.</ref> | ||
*On microscopic histopathological analysis, atypical [[signet ring cell]]s diffusely infiltrating the stomach wall, submucosal fibrosis and thickening, with minimal [[mucosa]]l involvement are characteristic findings of linitis plastica.<ref name="SchauerPeiper2011">{{cite journal|last1=Schauer|first1=M|last2=Peiper|first2=M|last3=Theisen|first3=J|last4=Knoefel|first4=W|title=Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment|journal=European Journal of Medical Research|volume=16|issue=1|year=2011|pages=29|issn=2047-783X|doi=10.1186/2047-783X-16-1-29}}</ref> | |||
*As a result of the infiltration and fibrosis, there is diffuse thickening and rigidity of the gastric wall, making the process of digestion difficult. | |||
*Mucosa is usually spared and rarely show superficial ulcerations on endoscopy, that has a wide differential diagnosis and the biopsies are usually negative, making the diagnosis even more difficult.<ref name="SchauerPeiper2011">{{cite journal|last1=Schauer|first1=M|last2=Peiper|first2=M|last3=Theisen|first3=J|last4=Knoefel|first4=W|title=Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment|journal=European Journal of Medical Research|volume=16|issue=1|year=2011|pages=29|issn=2047-783X|doi=10.1186/2047-783X-16-1-29}}</ref> | |||
*Although the lower mucosal and submucosal layers are mostly involved, the muscular and subserosal layers may also be infiltrated with the neoplastic cells.<ref>{{Cite journal | |||
| author = [[Bing Hu]], [[Nassim El Hajj]], [[Scott Sittler]], [[Nancy Lammert]], [[Robert Barnes]] & [[Aurelia Meloni-Ehrig]] | | author = [[Bing Hu]], [[Nassim El Hajj]], [[Scott Sittler]], [[Nancy Lammert]], [[Robert Barnes]] & [[Aurelia Meloni-Ehrig]] | ||
| title = Gastric cancer: Classification, histology and application of molecular pathology | | title = Gastric cancer: Classification, histology and application of molecular pathology | ||
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| doi = 10.3978/j.issn.2078-6891.2012.021 | | doi = 10.3978/j.issn.2078-6891.2012.021 | ||
| pmid = 22943016 | | pmid = 22943016 | ||
}}</ref> Metastasis to the [[peritoneum]], [[lymph node]]s and/or other organs usually occurs by the time linitis plastica is diagnosed. | }}</ref> | ||
*Metastasis to the [[peritoneum]], [[lymph node]]s and/or other organs usually occurs by the time linitis plastica is diagnosed. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
On gross pathology, thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the tumor cells are characteristic findings of linitis plastica.[1] On microscopic histopathological analysis, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening, with minimal mucosal involvement are characteristic findings of linitis plastica.
Pathophysiology
- On gross pathology, thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the tumor cells are characteristic findings of linitis plastica.[2]
- On microscopic histopathological analysis, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening, with minimal mucosal involvement are characteristic findings of linitis plastica.[3]
- As a result of the infiltration and fibrosis, there is diffuse thickening and rigidity of the gastric wall, making the process of digestion difficult.
- Mucosa is usually spared and rarely show superficial ulcerations on endoscopy, that has a wide differential diagnosis and the biopsies are usually negative, making the diagnosis even more difficult.[3]
- Although the lower mucosal and submucosal layers are mostly involved, the muscular and subserosal layers may also be infiltrated with the neoplastic cells.[4]
- Metastasis to the peritoneum, lymph nodes and/or other organs usually occurs by the time linitis plastica is diagnosed.
References
- ↑ Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.
- ↑ Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.
- ↑ 3.0 3.1 Schauer, M; Peiper, M; Theisen, J; Knoefel, W (2011). "Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment". European Journal of Medical Research. 16 (1): 29. doi:10.1186/2047-783X-16-1-29. ISSN 2047-783X.
- ↑ Bing Hu, Nassim El Hajj, Scott Sittler, Nancy Lammert, Robert Barnes & Aurelia Meloni-Ehrig (2012). "Gastric cancer: Classification, histology and application of molecular pathology". Journal of gastrointestinal oncology. 3 (3): 251–261. doi:10.3978/j.issn.2078-6891.2012.021. PMID 22943016. Unknown parameter
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