Sandbox: Bone DDx: Difference between revisions
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* Gradual dull bone pain at the tibial area | * Gradual dull bone pain at the tibial area | ||
* Leg swelling | * Leg swelling | ||
* Well-demarcated, eccentric/epicenteric, expansile, osteolytic, cortical lesion on X ray | * Well-demarcated, eccentric/epicenteric, expansile, osteolytic, cortical lesion on X ray | ||
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* Areas of lysis interspersed with areas of sclerosis | * Areas of lysis interspersed with areas of sclerosis | ||
* Lack of periosteal reaction | * Lack of periosteal reaction | ||
* Biphasic tumor | * Biphasic tumor | ||
* Islands of epithelial cells found in a fibrous stroma | |||
* Fibro-osseous component includes spindle cells | * Fibro-osseous component includes spindle cells | ||
* Epithelial component includes nests of basaloid cells | * Epithelial component includes nests of basaloid cells | ||
Revision as of 14:24, 23 November 2015
- 20-30 yo male
- Gradual dull bone pain at the tibial area
- Leg swelling
- Well-demarcated, eccentric/epicenteric, expansile, osteolytic, cortical lesion on X ray
- Located at the tibial diaphysis
- Areas of lysis interspersed with areas of sclerosis
- Lack of periosteal reaction
- Biphasic tumor
- Islands of epithelial cells found in a fibrous stroma
- Fibro-osseous component includes spindle cells
- Epithelial component includes nests of basaloid cells
- p53 gene mutations
- CK14 +ve
- CK19 +ve