Sandbox: Bone DDx: Difference between revisions

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* 20-30 yo female
* 1-5  yo children
* Bone pain and swelling
* Asymptomatic
* Pathologic fracture
* Minority of cases bone pain, swelling, and pathological fractures
* Paget disease of bone


* Localised bone tenderness
* Painless, firm, swelling located at the anterior tibia
 
* Bowed anterior bowing of the tibia
* Epiphyses of the femur
* Solitary expansile eccentrically-placed lytic lesion
* Intratumoral hemorrhage present
* Tumor extends into the subchondral plate
 
* Uniform and regular distribution of multinucleated giant cells and mononuclear stromal cells
* Hemorrhage, necrosis, and hemosiderin deposition
* Elevated mitotic figures
 
 
* Acid phosphatase +ve
* Alpha-1-antitrypsin +ve
* Alpha-1-antichymotrypsin +ve
* Ki-67 +ve

Revision as of 15:58, 24 November 2015

  • 1-5 yo children
  • Asymptomatic
  • Minority of cases bone pain, swelling, and pathological fractures
  • Painless, firm, swelling located at the anterior tibia
  • Bowed anterior bowing of the tibia
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