Delusional disorder differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Delusional disorder must be differentiated from other diseases that cause delusions, such as substrate deficiency, neurodegenerative disorders, vascular disease, other CNS disorders, infectious diseases, vitamin deficiencies, metabolic disorders, endocrinopathies, medications, toxins, substances and other mental disorders such as schizophrenia and mood disorders.

Differential Diagnosis

The cases of primary delusional disorder are uncommon. The occurrence of delusional thinking has many sources, mostly secondary to other conditions. Hence a practical principle is to detect or rule out other possible, usually more common causes of delusions, before arriving at the diagnosis. These include the following:

• Substrate deficiency
• Neurodegenerative disorders
• Vascular disease
• Other CNS disorders
• Infectious diseases
• Vitamin deficiencies
• Metabolic disorders
• Endocrinopathies
• Medications
• Toxins
• Substances
• Other mental disorders, including schizophrenia and mood disorder

Medical conditions associated with development of delusions is shown below in a tabular form:

Medical Conditions	Examples
Substrate deficiency	Hypoglycemia* Cerebral hypoxia* causes of cerebral hypoxia include cardiac insufficiency, pulmonary insufficiency, and severe anemia.
Neurodegenerative disorders	Alzheimer disease Pick disease Huntington disease Parkinson Disease Basal ganglia calcification (Fahr disease) Multiple sclerosis Metachromatic leukodystrophy
Vascular disease	Atherosclerotic vascular disease, especially when associated with diffuse, temporoparietal, or subcortical lesions Hypertensive encephalopathy Subarachnoid hemorrhage Temporal arteritis
Infectious disease	Human immunodeficiency virus/acquired immune deficiency syndrome (AIDS) Opportunistic infections in AIDS Encephalitis lethargica Creutzfeldt-Jakob disease Syphilis Malaria Acute viral encephalitis
Other CNS disorders	Brain tumors, especially temporal lobe and deep hemispheric tumors Epilepsy, especially complex partial seizure disorder, temporal lobe epilepsy Stroke* Brain abscess* CNS infection (meningitis, encephalitis)* Interictal psychosis Head trauma (subdural hematoma)* Anoxic brain injury Fat embolism Brain abscess* Landau Kleffner syndrome SSPE*
Vitamin deficiences	Vitamin B-12 deficiency Folate deficiency Thiamine deficiency Niacin deficiency
Metabolic disorder	Hypercalcemia Hyponatremia Hypoglycemia Uremia Hepatic encephalopathy Porphyria Electrolyte disturbance*Δ Hepatic failure* Postpartum psychosis* Electrolyte disturbance*Δ
Endocrinopathies	Addison disease Cushing syndrome Hyperthyroidism or hypothyroidism Panhypopituitarism Hashimoto thyroiditis (Hashimoto encephalopathy) Thyroid storm* Antiphospholipid syndrome Hashimoto thyroiditis (Hashimoto encephalopathy)
Medications	Analgesics such as meperidine, pentazocine, indomethacin Adrenocorticotropic hormones Anabolic steroids such as testosterone, methyltestosterone Anticholinergics such as atropine, scopolamine Antidepressants such as bupropion, others if triggering a manic switch Antiepileptics such as zonisamide, other anticonvulsants at high doses antimalarial such as mefloquine, chloroquine Anti-parkinsonian drugs such as levodopa, selegiline, amantadine, pramipexole, bromocriptine Antivirals such as abacavir, efavirenz, nevirapine, acyclovir Cardiovascular drugs such as digoxin, disopyramide, propafenone, quinidine Corticosteroids such as prednisone, dexamethasone, etc Inhalants such as toluene, butane, gasoline Interferons such as interferon alfa-2a/2b Over-the-counter (OTC) such as dextromethorphan (DXM), diphenhydramine, some decongestants Cimetidine Antibiotics (eg, cephalosporins, penicillin), disulfiram
Toxins	Carbon monoxide Organophosphates Heavy metals (eg, arsenic, manganese, mercury, thallium)
Other	Systemic lupus erythematosus
Substances	Amphetamines Cannabinoids such as marijuana, synthetic cannabinoids (ie, "spice"), dronabinol Alcohol and sedatives/hypnotics such as alcohol (intoxication or withdrawal), barbiturates and benzodiazepines (particularly withdrawal) Cannabis Stimulants such as cocaine, amphetamine/methamphetamine, methylphenidate, certain diet pills, "bath salts" (MDPV, mephedrone), MDMA/ecstasy Hallucinogens such as LSD, PCP (phencyclidine), ketamine, psilocybin-containing mushrooms, mescaline, synthetic "designer drugs" (eg, 2-CB, "N-Bomb" [25I-NBOMe]) , salvia divinorum

CNS: central nervous syndrome; SSPE: subacute sclerosing panencephalitis; SLE: systemic lupus erythematosus.

• Life-threatening.

Δ Acute psychosis may be seen with hypocalcemia and hypomagnesemia. Hypo- or hypernatremia may cause encephalopathy with delirium.