Pineal embryonal carcinoma: Difference between revisions
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==Overview== | ==Overview== | ||
*Pineal embryonal carcinoma is a relatively rare malignant neoplasm and accounts for a small prportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. A component of embryonal carcinoma is often found in mixed germ-cell tumours, in which case it usually the most aggressive component, and dictates prognosis. Pure pineal embryonal carcinoma tumors '''do not''' secrete [[Human chorionic gonadotropin|β-HCG]] or [[AFP]].<ref name=overviewpec1>Intracranial embryonal carcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-embryonal-carcinoma. Accessed on December 4, 2015</ref> | *Pineal embryonal carcinoma is a relatively rare malignant neoplasm and accounts for a small prportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. A component of embryonal carcinoma is often found in mixed germ-cell tumours, in which case it usually the most aggressive component, and dictates prognosis. Pure pineal embryonal carcinoma tumors '''do not''' secrete [[Human chorionic gonadotropin|β-HCG]] or [[AFP]].<ref name=overviewpec1>Intracranial embryonal carcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-embryonal-carcinoma. Accessed on December 4, 2015</ref> | ||
*On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by: | *On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:<ref name=micro1pec>Microscopic features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015</ref> | ||
**Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation | **Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation | ||
**Indistinct cell borders | **Indistinct cell borders | ||
**[[Nucleoli]] - key feature | **[[Nucleoli]] - key feature | ||
**Vesicular nuclei (clear, empty appearing nuclei) - key feature | **Vesicular nuclei (clear, empty appearing nuclei) - key feature | ||
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***Blastocyst-like | ***Blastocyst-like | ||
***Embryoid bodies - ball of cells in surrounded by empty space on three sides | ***Embryoid bodies - ball of cells in surrounded by empty space on three sides | ||
*Pineal embryonal carcinoma is demonstrated by positivity to [[tumor markers]] such as:<ref name=ihc1pec>IHC features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015</ref> | |||
==References== | ==References== | ||
Revision as of 19:18, 4 December 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords:
Overview
- Pineal embryonal carcinoma is a relatively rare malignant neoplasm and accounts for a small prportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. A component of embryonal carcinoma is often found in mixed germ-cell tumours, in which case it usually the most aggressive component, and dictates prognosis. Pure pineal embryonal carcinoma tumors do not secrete β-HCG or AFP.[1]
- On microscopic histopathological analysis, pineal embryonal carcinoma is characterized by:[2]
- Poorly differentiated, pleomorphic cells in cords, sheets, or papillary formation
- Indistinct cell borders
- Nucleoli - key feature
- Vesicular nuclei (clear, empty appearing nuclei) - key feature
- Necrosis - common
- Mitoses - common
- Variable architecture:
- Solid (predominant in ~55% of cases)
- Glandular (predominant in ~17% of cases)
- Papillary (predominant in ~11% of cases)
- Nested
- Micropapillary
- Anastomosing glandular
- Sieve-like glandular
- Pseudopapillary
- Blastocyst-like
- Embryoid bodies - ball of cells in surrounded by empty space on three sides
- Pineal embryonal carcinoma is demonstrated by positivity to tumor markers such as:[3]
References
- ↑ Intracranial embryonal carcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-embryonal-carcinoma. Accessed on December 4, 2015
- ↑ Microscopic features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015
- ↑ IHC features of embryonal carcinoma. Libre Pathology 2015. http://librepathology.org/wiki/index.php/Embryonal_carcinoma. Accessed on December 4, 2015