Myelodysplastic syndrome pathophysiology: Difference between revisions
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==Associated conditions== | ==Associated conditions== | ||
Myelodysplastic syndrome may be associated with:<ref name=Librepathology1>Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref> | Myelodysplastic syndrome may be associated with:<ref name=Librepathology1>Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref> | ||
*Fanconi syndrome | *Fanconi syndrome | ||
*Diamond-blackfan syndrome | *Diamond-blackfan syndrome | ||
*Shwachman-diamond syndrome | *Shwachman-diamond syndrome | ||
==Gross Pathology== | ==Gross Pathology== | ||
On gross pathology, a well , subcapsular tumor may be suggestive of myelodysplastic syndrome.<ref name=Librepathology>Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref> | On gross pathology, a well , subcapsular tumor may be suggestive of myelodysplastic syndrome.<ref name=Librepathology>Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015</ref> | ||
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*Dysmegakaryocytopoiesis | *Dysmegakaryocytopoiesis | ||
===Dyserythropoiesis=== | ===Dyserythropoiesis=== | ||
*Abnormal | *Abnormal red blood cell formation | ||
====Nuclear features==== | ====Nuclear features==== | ||
*Nuclear budding | *Nuclear budding | ||
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:*May be hard to see | :*May be hard to see | ||
*Karyorrhexis (nuclear fragmentation) | *Karyorrhexis (nuclear fragmentation) | ||
====Cytoplasmic features==== | ====Cytoplasmic features==== | ||
*Ring sideroblasts | *Ring sideroblasts | ||
:*Rim of RBC has ring of iron | :*Rim of RBC has ring of iron | ||
*Vacuolization | *Vacuolization | ||
===Dysgranulopoiesis=== | ===Dysgranulopoiesis=== | ||
====Nuclear features==== | ====Nuclear features==== | ||
Revision as of 19:08, 8 December 2015
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Myelodysplastic syndrome Microchapters |
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Differentiating Myelodysplastic syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Myelodysplastic syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of Myelodysplastic syndrome pathophysiology |
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Risk calculators and risk factors for Myelodysplastic syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
On microscopic histopathological analysis, dyserythropoiesis, dysgranulopoiesis, and dysmegakaryocytopoiesis are findings of myelodysplastic syndrome.[1]
Pathophysiology
Pathogenesis
Genetics
Associated conditions
Myelodysplastic syndrome may be associated with:[2]
- Fanconi syndrome
- Diamond-blackfan syndrome
- Shwachman-diamond syndrome
Gross Pathology
On gross pathology, a well , subcapsular tumor may be suggestive of myelodysplastic syndrome.[3]
Microscopic Pathology
On microscopic histopathological analysis, characteristic findings of myelodysplastic syndrome include:[1]
- Dyserythropoiesis
- Dysgranulopoiesis
- Dysmegakaryocytopoiesis
Dyserythropoiesis
- Abnormal red blood cell formation
Nuclear features
- Nuclear budding
- Intranuclear bridging (nuclei fail to separate post-division)
- Multinucleation
- Megablastoid change
- May be hard to see
- Karyorrhexis (nuclear fragmentation)
Cytoplasmic features
- Ring sideroblasts
- Rim of RBC has ring of iron
- Vacuolization
Dysgranulopoiesis
Nuclear features
Cytoplasmic features
Dysmegakaryocytopoiesis
Nuclear features
Gallery
Immunohistochemistry
References
- ↑ 1.0 1.1 Histologic features of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015