Myelodysplastic syndrome pathophysiology: Difference between revisions
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===Dysmegakaryocytopoiesis=== | ===Dysmegakaryocytopoiesis=== | ||
Abnormal megakaryocyte formation | *Abnormal megakaryocyte formation | ||
====Nuclear features==== | ====Nuclear features==== | ||
Micromegakaryoctes with hypolobated nuclei | *Micromegakaryoctes with hypolobated nuclei | ||
Non-lobated nuclei of any size | *Non-lobated nuclei of any size | ||
Multiple widely separated nuclear lobes | *Multiple widely separated nuclear lobes | ||
===Gallery=== | ===Gallery=== | ||
==Immunohistochemistry== | ==Immunohistochemistry== | ||
On immunohistochemistry, characteristic findings of myelodysplastic syndrome include: | |||
*CD34 - (myeloid) progenitor/precursor cells | |||
*CD117 - (myeloid) progenitor/precursor cells, mast cells | |||
*Tryptase - mast cells, immature basophils | |||
:*Uncommonly done | |||
*CD61 - megakaryocytes | |||
*CD42b - megakaryocytes | |||
*CD20 - B cells | |||
*CD3 - T cells | |||
*Glycophorin A - erythroid cells | |||
*Glycophorin C - erythroid cells | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 20:32, 8 December 2015
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Myelodysplastic syndrome Microchapters |
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Differentiating Myelodysplastic syndrome from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Myelodysplastic syndrome pathophysiology On the Web |
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American Roentgen Ray Society Images of Myelodysplastic syndrome pathophysiology |
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Risk calculators and risk factors for Myelodysplastic syndrome pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
On microscopic histopathological analysis, dyserythropoiesis, dysgranulopoiesis, and dysmegakaryocytopoiesis are findings of myelodysplastic syndrome.[1]
Pathophysiology
Pathogenesis
Genetics
Associated conditions
Myelodysplastic syndrome may be associated with:[2]
- Fanconi syndrome
- Diamond-blackfan syndrome
- Shwachman-diamond syndrome
Gross Pathology
On gross pathology, a well , subcapsular tumor may be suggestive of myelodysplastic syndrome.[3]
Microscopic Pathology
On microscopic histopathological analysis, characteristic findings of myelodysplastic syndrome include:[1]
- Dyserythropoiesis
- Dysgranulopoiesis
- Dysmegakaryocytopoiesis
Dyserythropoiesis
- Abnormal red blood cell formation
Nuclear features
- Nuclear budding
- Intranuclear bridging (nuclei fail to separate post-division)
- Multinucleation
- Megablastoid change
- May be hard to see
- Karyorrhexis (nuclear fragmentation)
Cytoplasmic features
- Ring sideroblasts
- Rim of RBC has ring of iron
- Vacuolization
Dysgranulopoiesis
- Abnormal granulocyte formation
Nuclear features
- Nuclear hypolobation (pseudo Pelger-Huët)
- Hypersegmentation
- May be seen in vitamin B12 deficiency
Cytoplasmic features
- Cytoplasmic hypogranulation
- Pseudo-Chediak-Higashi granules
- Small size
Dysmegakaryocytopoiesis
- Abnormal megakaryocyte formation
Nuclear features
- Micromegakaryoctes with hypolobated nuclei
- Non-lobated nuclei of any size
- Multiple widely separated nuclear lobes
Gallery
Immunohistochemistry
On immunohistochemistry, characteristic findings of myelodysplastic syndrome include:
- CD34 - (myeloid) progenitor/precursor cells
- CD117 - (myeloid) progenitor/precursor cells, mast cells
- Tryptase - mast cells, immature basophils
- Uncommonly done
- CD61 - megakaryocytes
- CD42b - megakaryocytes
- CD20 - B cells
- CD3 - T cells
- Glycophorin A - erythroid cells
- Glycophorin C - erythroid cells
References
- ↑ 1.0 1.1 Histologic features of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015
- ↑ Associations of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 8, 2015