Adenocarcinoma of the lung pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
== Histopathology== | |||
Adenocarcinoma of the lung tends to stain mucin positive as it is derived from the mucus producing glands of the lungs. Similar to other adenocarcinoma, if this tumor is well differentiated (low grade) it will resemble the normal glandular structure. Poorly differentiated adenocarcinoma will not resemble the normal glands (high grade) and will be detected by seeing that they stain positive for mucin (which the glands produce).<ref>[http://radiology.uchc.edu/eAtlas/nav/msLung.htm Diseases of Lung<!-- Bot generated title -->]</ref><ref>[http://radiology.uchc.edu/eAtlas/RESP/1624b.htm Adenocarcinoma of Lung (Mucin Stain)]</ref> Adenocarcinoma can also be distinguished by staining for [[TTF-1]], a [[cell marker]] for adenocarcinoma.<ref name=WCR20145.1/> | |||
To reveal the adenocarcinomatous lineage of the solid variant, demonstration of intracellular mucin production may be performed. Foci of squamous metaplasia and dysplasia may be present in the epithelium proximal to adenocarcinomas, but these are not the precursor lesions for this tumor. Rather, the precursor of peripheral adenocarcinomas has been termed ''atypical adenomatous hyperplasia'' (AAH).<ref name=Kumar-adenocarcinoma/> Microscopically, AAH is a well-demarcated focus of epithelial proliferation, containing cuboidal to low-columnar cells resembling [[club cells]] or [[type II pneumocyte]]s.<ref name=Kumar-adenocarcinoma/> These demonstrate various degrees of cytologic atypia, including [[hyperchromasia]], [[pleomorphism (cytology)|pleomorphism]], prominent [[nucleoli]].<ref name=Kumar-adenocarcinoma/> However, the atypia is not to the extent as seen in frank adenocarcinomas.<ref name=Kumar-adenocarcinoma/> Lesions of AAH are monoclonal, and they share many of the molecular aberrations (like [[KRAS]] mutations) that are associated with adenocarcinomas.<ref name=Kumar-adenocarcinoma/> | |||
==References== | ==References== | ||
Revision as of 18:33, 9 December 2015
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Adenocarcinoma of the Lung Microchapters |
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Differentiating Adenocarcinoma of the Lung from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Histopathology
Adenocarcinoma of the lung tends to stain mucin positive as it is derived from the mucus producing glands of the lungs. Similar to other adenocarcinoma, if this tumor is well differentiated (low grade) it will resemble the normal glandular structure. Poorly differentiated adenocarcinoma will not resemble the normal glands (high grade) and will be detected by seeing that they stain positive for mucin (which the glands produce).[1][2] Adenocarcinoma can also be distinguished by staining for TTF-1, a cell marker for adenocarcinoma.[3]
To reveal the adenocarcinomatous lineage of the solid variant, demonstration of intracellular mucin production may be performed. Foci of squamous metaplasia and dysplasia may be present in the epithelium proximal to adenocarcinomas, but these are not the precursor lesions for this tumor. Rather, the precursor of peripheral adenocarcinomas has been termed atypical adenomatous hyperplasia (AAH).[4] Microscopically, AAH is a well-demarcated focus of epithelial proliferation, containing cuboidal to low-columnar cells resembling club cells or type II pneumocytes.[4] These demonstrate various degrees of cytologic atypia, including hyperchromasia, pleomorphism, prominent nucleoli.[4] However, the atypia is not to the extent as seen in frank adenocarcinomas.[4] Lesions of AAH are monoclonal, and they share many of the molecular aberrations (like KRAS mutations) that are associated with adenocarcinomas.[4]
References
- ↑ Diseases of Lung
- ↑ Adenocarcinoma of Lung (Mucin Stain)
- ↑ Invalid
<ref>tag; no text was provided for refs namedWCR20145.1 - ↑ 4.0 4.1 4.2 4.3 4.4 Invalid
<ref>tag; no text was provided for refs namedKumar-adenocarcinoma