Myelodysplastic syndrome differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Myelodysplastic syndrome must be differentiated from other diseases that cause [[anemia]], [[neutropenia]], and [[thrombocytopenia]], such as vitamin deficiencies, toxic exposure, biologic agents, heavy metals, chemotherapy, and infections.<ref name=Librepathology3>Differential diagnosis of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 9, 2015</ref><ref name="MerrillSmith2011">{{cite journal|last1=Merrill|first1=Andrea L.|last2=Smith|first2=Hedy|title=Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome|journal=Case Reports in Hematology|volume=2011|year=2011|pages=1–4|issn=2090-6560|doi=10.1155/2011/560106}}</ref><ref name="DeZernSekeres2014">{{cite journal|last1=DeZern|first1=A. E.|last2=Sekeres|first2=M. A.|title=The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure|journal=The Oncologist|volume=19|issue=7|year=2014|pages=735–745|issn=1083-7159|doi=10.1634/theoncologist.2014-0056}}</ref> | Myelodysplastic syndrome must be differentiated from other diseases that cause [[anemia]], [[neutropenia]], and [[thrombocytopenia]], such as vitamin deficiencies, toxic exposure, biologic agents, heavy metals, chemotherapy, and infections.<ref name=Librepathology3>Differential diagnosis of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 9, 2015</ref><ref name="MerrillSmith2011">{{cite journal|last1=Merrill|first1=Andrea L.|last2=Smith|first2=Hedy|title=Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome|journal=Case Reports in Hematology|volume=2011|year=2011|pages=1–4|issn=2090-6560|doi=10.1155/2011/560106}}</ref><ref name="DeZernSekeres2014">{{cite journal|last1=DeZern|first1=A. E.|last2=Sekeres|first2=M. A.|title=The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure|journal=The Oncologist|volume=19|issue=7|year=2014|pages=735–745|issn=1083-7159|doi=10.1634/theoncologist.2014-0056}}</ref> | ||
==Myelodysplastic syndrome differential diagnosis== | ==Myelodysplastic syndrome differential diagnosis== | ||
Myelodysplastic syndrome must be differentiated from other diseases that cause [[anemia]], [[neutropenia]], and [[thrombocytopenia]], such as:<ref name=Librepathology3>Differential diagnosis of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 9, 2015</ref><ref name="MerrillSmith2011">{{cite journal|last1=Merrill|first1=Andrea L.|last2=Smith|first2=Hedy|title=Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome|journal=Case Reports in Hematology|volume=2011|year=2011|pages=1–4|issn=2090-6560|doi=10.1155/2011/560106}}</ref><ref name="DeZernSekeres2014">{{cite journal|last1=DeZern|first1=A. E.|last2=Sekeres|first2=M. A.|title=The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure|journal=The Oncologist|volume=19|issue=7|year=2014|pages=735–745|issn=1083-7159|doi=10.1634/theoncologist.2014-0056}}</ref> | Myelodysplastic syndrome must be differentiated from other diseases that cause [[anemia]], [[neutropenia]], and [[thrombocytopenia]], such as:<ref name=Librepathology3>Differential diagnosis of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 9, 2015</ref><ref name="MerrillSmith2011">{{cite journal|last1=Merrill|first1=Andrea L.|last2=Smith|first2=Hedy|title=Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome|journal=Case Reports in Hematology|volume=2011|year=2011|pages=1–4|issn=2090-6560|doi=10.1155/2011/560106}}</ref><ref name="DeZernSekeres2014">{{cite journal|last1=DeZern|first1=A. E.|last2=Sekeres|first2=M. A.|title=The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure|journal=The Oncologist|volume=19|issue=7|year=2014|pages=735–745|issn=1083-7159|doi=10.1634/theoncologist.2014-0056}}</ref> | ||
*Aplastic anemia | ===Inherited cytopenia=== | ||
*Pure red cell aplasia | *[[Aplastic anemia]] | ||
*[[Fanconi anemia]] | |||
*[[Pure red cell aplasia]] | |||
*[[Shwachman-Diamond syndrome]] | |||
*Large granular lymphocytosis | *Large granular lymphocytosis | ||
*Parovirus B19 infection | *Parovirus B19 infection | ||
*Myeloproliferative neoplasms | *Myeloproliferative neoplasms | ||
*Congenital hematopoietic disorder | *Congenital hematopoietic disorder | ||
*Congenital dyserythropoietic anemia | *[[Congenital dyserythropoietic anemia]] | ||
===Acquired cytopenia=== | |||
*[[Paroxysmal nocturnal hemoglobinuria]] | |||
*Toxic exposures | |||
*Biologic agents | |||
*Heavy metals | |||
*Chemotherapy | |||
===Reactive Cytopenia=== | ===Reactive Cytopenia=== | ||
*Nutritional deficiency | *Nutritional deficiency | ||
:*Vitamin B12 defeciency | :*Vitamin B12 defeciency | ||
:*Folate defeciency | :*Folate defeciency | ||
*Infections | *Infections | ||
==References== | ==References== | ||
Revision as of 01:23, 14 December 2015
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Differentiating Myelodysplastic syndrome from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Myelodysplastic syndrome must be differentiated from other diseases that cause anemia, neutropenia, and thrombocytopenia, such as vitamin deficiencies, toxic exposure, biologic agents, heavy metals, chemotherapy, and infections.[1][2][3]
Myelodysplastic syndrome differential diagnosis
Myelodysplastic syndrome must be differentiated from other diseases that cause anemia, neutropenia, and thrombocytopenia, such as:[1][2][3]
Inherited cytopenia
- Shwachman-Diamond syndrome
- Large granular lymphocytosis
- Parovirus B19 infection
- Myeloproliferative neoplasms
- Congenital hematopoietic disorder
- Congenital dyserythropoietic anemia
Acquired cytopenia
- Paroxysmal nocturnal hemoglobinuria
- Toxic exposures
- Biologic agents
- Heavy metals
- Chemotherapy
Reactive Cytopenia
- Nutritional deficiency
- Vitamin B12 defeciency
- Folate defeciency
- Infections
References
- ↑ 1.0 1.1 Differential diagnosis of myelodysplastic syndromes. Librepathology (2015). http://librepathology.org/wiki/index.php/Myelodysplastic_syndromes. Accessed on December 9, 2015
- ↑ 2.0 2.1 Merrill, Andrea L.; Smith, Hedy (2011). "Myelodysplastic Syndrome and Autoimmunity: A Case Report of an Unusual Presentation of Myelodysplastic Syndrome". Case Reports in Hematology. 2011: 1–4. doi:10.1155/2011/560106. ISSN 2090-6560.
- ↑ 3.0 3.1 DeZern, A. E.; Sekeres, M. A. (2014). "The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure". The Oncologist. 19 (7): 735–745. doi:10.1634/theoncologist.2014-0056. ISSN 1083-7159.