Linitis plastica screening: Difference between revisions

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==Overview==
==Overview==
Patients who have a relative with hereditary diffuse gastric [[adenocarcinoma]] (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref>
There is insufficient evidence to recommend routine screening for linitis plastica.  


==Screening==
==Screening==
*Patients who have a relative with hereditary diffuse gastric adenocarcinoma (HDGC) should be screened earlier for ''CDH1'' gene mutations.<ref name=me>Hereditary diffuse gastric cancer. Genetics Home Reference. http://ghr.nlm.nih.gov/condition/hereditary-diffuse-gastric-cancer#definition Accessed on December 10, 2015</ref>
There is insufficient evidence to recommend routine screening for linitis plastica.  
*Indication for prophylactic [[gastrectomy]] include CDH1 positive patients.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348  }} </ref>
**The disease [[penetrance]] for the hereditary form is 80%, resulting in a very high risk of developing the cancer.


==References==
==References==

Revision as of 19:28, 20 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

There is insufficient evidence to recommend routine screening for linitis plastica.

Screening

There is insufficient evidence to recommend routine screening for linitis plastica.

References


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