Linitis plastica overview: Difference between revisions
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==Overview== | ==Overview== | ||
The term "Linitis plastica" was first coined by Dr. William Brinton, an English physician, in 1854.<ref name=nb>Linitis plastica. Radiopedia.org. http://radiopaedia.org/articles/linitis-plastica Accessed on November 17, 2015</ref> Napoleon Bonaparte, a French military and political leader and many members of his family are thought to have died from this type of cancer, although it is believed by others that he may have died from [[arsenic]] poisoning.<ref>{{cite journal |author=Bevan S, Houlston RS |title=Genetic predisposition to gastric cancer |journal=QJM : monthly journal of the Association of Physicians |volume=92 |issue=1 |pages=5–10 |year=1999 |pmid=10209666 |doi= 10.1093/qjmed/92.1.5|url=http://qjmed.oxfordjournals.org/cgi/content/full/92/1/5}}</ref> Development of linitis plastica is the result of genetic mutation in the ''CDH1'' ([[E-cadherin]]) gene, that is responsible for intercellular adhesions.<ref name= | The term "Linitis plastica" was first coined by Dr. William Brinton, an English physician, in 1854.<ref name=nb>Linitis plastica. Radiopedia.org. http://radiopaedia.org/articles/linitis-plastica Accessed on November 17, 2015</ref> Napoleon Bonaparte, a French military and political leader and many members of his family are thought to have died from this type of cancer, although it is believed by others that he may have died from [[arsenic]] poisoning.<ref>{{cite journal |author=Bevan S, Houlston RS |title=Genetic predisposition to gastric cancer |journal=QJM : monthly journal of the Association of Physicians |volume=92 |issue=1 |pages=5–10 |year=1999 |pmid=10209666 |doi= 10.1093/qjmed/92.1.5|url=http://qjmed.oxfordjournals.org/cgi/content/full/92/1/5}}</ref> Development of linitis plastica is the result of genetic mutation in the ''CDH1'' ([[E-cadherin]]) gene, that is responsible for intercellular adhesions.<ref name=me>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on December 8, 2015.</ref> On [[gross pathology]], thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the [[tumor cell]]s are characteristic findings of linitis plastica.<ref name=pl>Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.</ref> On microscopic histopathological analysis, atypical [[signet ring cell]]s diffusely infiltrating the stomach wall, [[submucosal]] [[fibrosis]] and thickening, with minimal [[mucosa]]l involvement are characteristic findings of linitis plastica. Linitis plastica usually affects individuals of the Asian race, particularly the Japanese.<ref name=pl>Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on December 7, 2015.</ref> The presence of [[metastasis]] is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.<ref name=me>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> Total [[gastrectomy]] is recommended for the management of local disease and as a prophylactic surgery in patients with hereditary form of linitis plastica. <ref name=me>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on December 9, 2015.</ref> | ||
==References== | ==References== | ||
Revision as of 03:09, 14 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Synonyms and keywords: Brinton's disease, Leather bottle stomach
Overview
The term "Linitis plastica" was first coined by Dr. William Brinton, an English physician, in 1854.[1] Napoleon Bonaparte, a French military and political leader and many members of his family are thought to have died from this type of cancer, although it is believed by others that he may have died from arsenic poisoning.[2] Development of linitis plastica is the result of genetic mutation in the CDH1 (E-cadherin) gene, that is responsible for intercellular adhesions.[3] On gross pathology, thick, rigid, leather bottle-like stomach from diffuse infiltration of the stomach wall by the tumor cells are characteristic findings of linitis plastica.[4] On microscopic histopathological analysis, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening, with minimal mucosal involvement are characteristic findings of linitis plastica. Linitis plastica usually affects individuals of the Asian race, particularly the Japanese.[4] The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.[3] Total gastrectomy is recommended for the management of local disease and as a prophylactic surgery in patients with hereditary form of linitis plastica. [3]
References
- ↑ Linitis plastica. Radiopedia.org. http://radiopaedia.org/articles/linitis-plastica Accessed on November 17, 2015
- ↑ Bevan S, Houlston RS (1999). "Genetic predisposition to gastric cancer". QJM : monthly journal of the Association of Physicians. 92 (1): 5–10. doi:10.1093/qjmed/92.1.5. PMID 10209666.
- ↑ 3.0 3.1 3.2 Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on December 8, 2015.
- ↑ 4.0 4.1 Linitis plastica. Wikipedia. https://en.wikipedia.org/wiki/Linitis_plastica Accessed on November 18, 2015.