Myxoma classification: Difference between revisions
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==Classification== | ==Classification== | ||
Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: '''typical''' and '''atypical'''. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there. | * Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: '''typical''' and '''atypical'''. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there. | ||
In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the [[left ventricle]] (5%). <ref> Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015 </ref> <ref name="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref> There is also recurrence after [[surgical]] excision (12%–22%) and an association with other conditions, such as the [[Carney complex]]. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.<ref name|classification="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref> | * In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the [[left ventricle]] (5%). <ref> Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015 </ref> <ref name="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref> There is also recurrence after [[surgical]] excision (12%–22%) and an association with other conditions, such as the [[Carney complex]]. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.<ref name|classification="pmid10903697">{{cite journal |vauthors=Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR |title=Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation |journal=Radiographics |volume=20 |issue=4 |pages=1073–103; quiz 1110–1, 1112 |year=2000 |pmid=10903697 |doi=10.1148/radiographics.20.4.g00jl081073 |url=}}</ref> | ||
Distribution: | * Distribution: | ||
* Atria (95%) | ** Atria (95%) | ||
***Left (75%) | |||
***Right (20%) | |||
*Ventricles (5%) | ** Ventricles (5%) | ||
There is no established histological differentiation both type of myxomas (typical and atypical).<ref name="pmid3951243">{{cite journal |vauthors=McCarthy PM, Piehler JM, Schaff HV, Pluth JR, Orszulak TA, Vidaillet HJ, Carney JA |title=The significance of multiple, recurrent, and "complex" cardiac myxomas |journal=J. Thorac. Cardiovasc. Surg. |volume=91 |issue=3 |pages=389–96 |year=1986 |pmid=3951243 |doi= |url=}}</ref> | |||
* There is no established histological differentiation both type of myxomas (typical and atypical).<ref name="pmid3951243">{{cite journal |vauthors=McCarthy PM, Piehler JM, Schaff HV, Pluth JR, Orszulak TA, Vidaillet HJ, Carney JA |title=The significance of multiple, recurrent, and "complex" cardiac myxomas |journal=J. Thorac. Cardiovasc. Surg. |volume=91 |issue=3 |pages=389–96 |year=1986 |pmid=3951243 |doi= |url=}}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 21:02, 15 December 2015
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Myxoma classification On the Web |
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American Roentgen Ray Society Images of Myxoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Cardiac myxomas are classified by the World Health Organization (WHO) histological classification of tumors of the heart, as "Benign tumors and tumor-like lesions" and categorized into a type of pluripotent mesenchymal tumor. According to the WHO , cardiac myxoma is a neoplasm composed of stellate to plump, cytologically bland mesenchymal cells set in a myxoid stroma.[1][2][3]
Classification
- Based on the location and biological behavior of symptoms, cardiac myxomas may be classified into two groups: typical and atypical. In typical cases, cardiac myxomas are almost always single, and there is a striking predilection for the left atrium, with approximately 75-86% occurring there.
- In atypical cases, presentation is usually early and multicentricity is more common. They are more frequently located on the right side of the heart (38%), or in the left ventricle (5%). [4] [3] There is also recurrence after surgical excision (12%–22%) and an association with other conditions, such as the Carney complex. Among patients with this syndrome, they tend to be younger, male, and have familial predisposition for cardiac myxoma.[5]
- Distribution:
- Atria (95%)
- Left (75%)
- Right (20%)
- Ventricles (5%)
- Atria (95%)
- There is no established histological differentiation both type of myxomas (typical and atypical).[6]
References
- ↑ Amano J, Nakayama J, Yoshimura Y, Ikeda U (2013). "Clinical classification of cardiovascular tumors and tumor-like lesions, and its incidences". Gen Thorac Cardiovasc Surg. 61 (8): 435–47. doi:10.1007/s11748-013-0214-8. PMC 3732772. PMID 23460447.
- ↑ cite journal |vauthors=Wold LE, Lie JT |title=Cardiac myxomas: a clinicopathologic profile |journal=Am. J. Pathol. |volume=101 |issue=1 |pages=219–40 |year=1980 |pmid=7446701 |pmc=1903582 |doi= |url=}
- ↑ 3.0 3.1 Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR (2000). "Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation". Radiographics. 20 (4): 1073–103, quiz 1110–1, 1112. doi:10.1148/radiographics.20.4.g00jl081073. PMID 10903697.
- ↑ Cardiac Myxoma.Radiopedia.URL http://radiopaedia.org/articles/cardiac-myxoma accessed on November 13,2015
- ↑ Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR (2000). "Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation". Radiographics. 20 (4): 1073–103, quiz 1110–1, 1112. doi:10.1148/radiographics.20.4.g00jl081073. PMID 10903697.
- ↑ McCarthy PM, Piehler JM, Schaff HV, Pluth JR, Orszulak TA, Vidaillet HJ, Carney JA (1986). "The significance of multiple, recurrent, and "complex" cardiac myxomas". J. Thorac. Cardiovasc. Surg. 91 (3): 389–96. PMID 3951243.