Babesiosis pathophysiology: Difference between revisions
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==Pathogenesis== | ==Pathogenesis== | ||
[[Image:Babesia LifeCycle.gif|left|400px|thumb| Life cycle of ''B. microti'' <br> [http://www.cdc.gov/dpdx/babesiosis/index.html <font size="-2">'' | [[Image:Babesia LifeCycle.gif|left|400px|thumb| Life cycle of ''B. microti'' <br> [http://www.cdc.gov/dpdx/babesiosis/index.html <font size="-2">''Babesia Biology CDC''</font>]] | ||
The ''Babesia microti'' life cycle involves two primary components, an infected vertebrate host (primarily the white-footed mouse "Peromyscus leucopus"), and a tick in the genus ''Ixodes''. <ref> CDC Babesiosis. | The ''Babesia microti'' life cycle involves two primary components, an infected vertebrate host (primarily the white-footed mouse "Peromyscus leucopus"), and a tick in the genus ''Ixodes''. <ref> CDC Babesiosis. Biology. http://www.cdc.gov/parasites/babesiosis/biology.html Accessed December 21, 2016 </ref> | ||
1.During a blood meal, a ''Babesia''-infected tick introduces [[sporozoites]] into the mouse host. <br> | 1.During a blood meal, a ''Babesia''-infected tick introduces [[sporozoites]] into the mouse host. <br> | ||
Revision as of 18:47, 21 December 2015
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Babesiosis Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Tamar Sifri [2] Associate Editor(s)-in-Chief: Ilan Dock, B.S.
Overview
Babesia parasites reproduce in red blood cells, where they can be seen as cross-shaped inclusions (4 merozoites asexually budding but attached together forming a structure looking like a "Maltese Cross") and cause hemolytic anemia, quite similar to malaria. Note that unlike the Plasmodium parasites that cause malaria, Babesia species lack an exo-erythrotic phase, so the liver is usually not affected.
Pathogenesis
[http://www.cdc.gov/dpdx/babesiosis/index.html Babesia Biology CDC
The Babesia microti life cycle involves two primary components, an infected vertebrate host (primarily the white-footed mouse "Peromyscus leucopus"), and a tick in the genus Ixodes. [1]
1.During a blood meal, a Babesia-infected tick introduces sporozoites into the mouse host.
2.Sporozoites enter erythrocytes and undergo asexual reproduction (budding).
3.In the blood, some parasites differentiate into male and female gametes, although these cannot be distinguished by light microscopy.
4.The definitive host is the tick. Once ingested by an appropriate tick, gametes unite and undergo a sporogonic cycle resulting in sporozoites (5).
5.Transovarial transmission (also known as vertical, or hereditary, transmission) has been documented for "large" Babesia spp. but not for the "small" babesiae, such as B. microti (A).
6.Humans enter the cycle when bitten by infected ticks. During a blood meal, a Babesia-infected tick introduces sporozoites into the human host.
7.Sporozoites enter erythrocytes (B) and undergo (budding).
8.Multiplication of the blood-stage parasites is responsible for the clinical manifestations of the disease. Humans are usually dead-end hosts. However, human-to-human transmission is well recognized to occur via contaminated blood transfusions.
References
- ↑ CDC Babesiosis. Biology. http://www.cdc.gov/parasites/babesiosis/biology.html Accessed December 21, 2016