Langerhans cell histiocytosis pathophysiology: Difference between revisions
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==Gross Pathology== | ==Gross Pathology== | ||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:<ref name= | On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:<ref name=microscopy>Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015</ref> | ||
*Langerhans cells histiocytes | *Langerhans cells histiocytes | ||
:*Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | :*Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm. | ||
::*Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus. | ::*Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus. | ||
::*May be called "buttock cells". | ::*May be called "buttock cells". | ||
==Immunohistochemistry== | |||
Langerhans cell histiocytosis is demonstrated by positivity to:<ref name=librepathologyIHC>Immunohistochemistry of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015</ref> | |||
*CD1a positive | |||
*S100 positive | |||
*CD207 (AKA Langerin) positive | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:38, 21 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Pathophysiology
Pathogenesis
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:[1]
- Langerhans cells histiocytes
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus.
- May be called "buttock cells".
Immunohistochemistry
Langerhans cell histiocytosis is demonstrated by positivity to:[2]
- CD1a positive
- S100 positive
- CD207 (AKA Langerin) positive
References
- ↑ Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
- ↑ Immunohistochemistry of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015