Langerhans cell histiocytosis pathophysiology: Difference between revisions
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Revision as of 13:29, 22 December 2015
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Langerhans cell histiocytosis Microchapters |
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Differentiating Langerhans cell histiocytosis from other Diseases |
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Diagnosis |
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Langerhans cell histiocytosis pathophysiology On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Pathophysiology
Pathogenesis
Genetics
Associated Conditions
Gross Pathology
Microscopic Pathology
On microscopic histopathological analysis, findings of langerhans cell histiocytosis include:[1]
- Langerhans cells histiocytes
- Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
- Nucleus may look like a "coffee bean", that is have nuclear grooves, appearance dependent on the rotation of the nucleus.
- May be called "buttock cells".
Immunohistochemistry
Langerhans cell histiocytosis is demonstrated by positivity to:[2]
- CD1a positive
- S100 positive
- CD207 (AKA Langerin) positive
Electron Microscopy
On electron microscopy, findings of langerhans cell histiocytosis include:[3]
- Birbeck granules
- Cell membrane invagination
- Electron dense, cytoplasmic tennis racket-like body
References
- ↑ Microscopic features of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
- ↑ Immunohistochemistry of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015
- ↑ Electron microscopy of langerhans cell histiocytosis. Librepathology (2015). http://librepathology.org/wiki/index.php/Langerhans_cell_histiocytosis. December 21, 2015