Desmoid tumor medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
==Medical Therapy== | ==Medical Therapy== | ||
Treatment may consist of watching and waiting, complete [[surgery|surgical]] removal, [[radiation therapy]], [[antiestrogen]]s (ex. [[Tamoxifen]]), [[non-steroidal anti-inflammatory drug|NSAIDs]], [[chemotherapy]] or microwave ablation. | |||
Patients with desmoid tumors should be evaluated by a multi-disciplinary team of surgeons, medical oncologists, radiation oncologists, geneticists and nurses. There is no cure for desmoid tumors and when possible patients are encouraged to enlist in clinical trials. <ref>http://www.dtrf.org/index.php/about-br-desmoid-tumors/about-desmoid-tumors.html</ref> | |||
A biopsy is always indicated as the definitive method to determine nature of the tumour. Management of these lesions is complex, the main problem being the high rates of recurrence in FAP associated disease. Conversely, for intra-abdominal fibromatosis without evidence of FAP, although extensive surgery may still be required for local symptoms, the risk of recurrence appears to be lower.<ref name="pmid22359346">{{cite journal |author=Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC|title=Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis |journal=BJS. |volume=99 |issue=5 |pages=706–13|year=2012 |doi=10.1002/bjs.8703 |pmid=22359346}}</ref> Wide surgical resection with clear margins is the most widely practiced technique with radiation, chemotherapy, or hormonal therapy being used to reduce the risk of recurrence.<ref name="pmid22370045"/> | |||
Current experimental studies are being done with Gleevec ([[Imatinib]]) and Nexavar ([[sorafenib]]) for treatment of desmoid tumors, and show promising success rates. | |||
Revision as of 17:53, 19 January 2016
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Desmoid tumor Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
Medical Therapy
Treatment may consist of watching and waiting, complete surgical removal, radiation therapy, antiestrogens (ex. Tamoxifen), NSAIDs, chemotherapy or microwave ablation.
Patients with desmoid tumors should be evaluated by a multi-disciplinary team of surgeons, medical oncologists, radiation oncologists, geneticists and nurses. There is no cure for desmoid tumors and when possible patients are encouraged to enlist in clinical trials. [1]
A biopsy is always indicated as the definitive method to determine nature of the tumour. Management of these lesions is complex, the main problem being the high rates of recurrence in FAP associated disease. Conversely, for intra-abdominal fibromatosis without evidence of FAP, although extensive surgery may still be required for local symptoms, the risk of recurrence appears to be lower.[2] Wide surgical resection with clear margins is the most widely practiced technique with radiation, chemotherapy, or hormonal therapy being used to reduce the risk of recurrence.[3]
Current experimental studies are being done with Gleevec (Imatinib) and Nexavar (sorafenib) for treatment of desmoid tumors, and show promising success rates.
Reference
- ↑ http://www.dtrf.org/index.php/about-br-desmoid-tumors/about-desmoid-tumors.html
- ↑ Wilkinson MJ, Fitzgerald JE, Thomas JM, Hayes AJ, Strauss DC (2012). "Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis". BJS. 99 (5): 706–13. doi:10.1002/bjs.8703. PMID 22359346.
- ↑ Invalid
<ref>tag; no text was provided for refs namedpmid22370045