Rocky Mountain spotted fever medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
The mainstay of therapy for rocky mountain spotted fever is | The mainstay of therapy for rocky mountain spotted fever is doxycycline. Pharmacologic therapy for rocky mountain spotted fever includes either [[Doxycycline]] or [[Chloramphenicol]]. | ||
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*Failure to respond to doxycycline argues against a diagnosis of RMSF. | *Failure to respond to doxycycline argues against a diagnosis of RMSF. | ||
*Severely ill patients may require longer periods before their fever resolves, especially if they have experienced damage to multiple organ systems. | *Severely ill patients may require longer periods before their fever resolves, especially if they have experienced damage to multiple organ systems. | ||
*Preventive therapy in non-ill patients who have had recent tick bites is not recommended and may, in fact, only delay the onset of disease. <ref name="RMSF Treatment CDC”> | *Preventive therapy in non-ill patients who have had recent tick bites is not recommended and may, in fact, only delay the onset of disease. <ref name="RMSF Treatment CDC”">Rocky Mountain Spotted Fever Symptoms. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/symptoms/index.html Accessed on December 30, 2015</ref> | ||
===Antimicrobial regimens=== | ===Antimicrobial regimens=== | ||
*'''Rocky Mountain spotted fever'''<ref name="RMSF Treatment CDC”> | *'''Rocky Mountain spotted fever'''<ref name="RMSF Treatment CDC”">Rocky Mountain Spotted Fever Symptoms. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/symptoms/index.html Accessed on December 30, 2015</ref> | ||
:*'''1. Adults''' | :*'''1. Adults''' | ||
::*Preferred regimen: [[Doxycycline]] 100 mg PO q12h for 7-14 days | ::*Preferred regimen: [[Doxycycline]] 100 mg PO q12h for 7-14 days | ||
Revision as of 20:11, 11 January 2016
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Rocky Mountain spotted fever Microchapters |
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Differentiating Rocky Mountain spotted fever from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Rocky Mountain spotted fever medical therapy On the Web |
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American Roentgen Ray Society Images of Rocky Mountain spotted fever medical therapy |
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Directions to Hospitals Treating Rocky Mountain spotted fever |
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Risk calculators and risk factors for Rocky Mountain spotted fever medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
The mainstay of therapy for rocky mountain spotted fever is doxycycline. Pharmacologic therapy for rocky mountain spotted fever includes either Doxycycline or Chloramphenicol.
Medical Therapy
- Doxycycline is the mainstay of therapy for Rocky Mountain spotted fever. Use of antibiotics other than doxycycline is associated with a higher risk of fatal outcome.
- Treatment is most effective at preventing death if doxycycline is started in the first 5 days of symptoms.
- Empirical antibiotic therapy should be initiated immediately when there is a suspicion of Rocky Mountain spotted fever on the basis of clinical and epidemiologic findings.
- Treatment should not be delayed until laboratory confirmation is obtained.
- If the patient is treated within the first 4-5 days of the disease, fever generally subsides within 24-72 hours.
- Failure to respond to doxycycline argues against a diagnosis of RMSF.
- Severely ill patients may require longer periods before their fever resolves, especially if they have experienced damage to multiple organ systems.
- Preventive therapy in non-ill patients who have had recent tick bites is not recommended and may, in fact, only delay the onset of disease. [1]
Antimicrobial regimens
- Rocky Mountain spotted fever[1]
- 1. Adults
- Preferred regimen: Doxycycline 100 mg PO q12h for 7-14 days
- Note: Treatment with antibiotic agents other than doxycycline is associated with worse outcomes.
- 2. Children under 45kg
- Preferred regimen: Doxycycline 2.2 mg/kg PO q12h for 7-14 days
References
- ↑ 1.0 1.1 Rocky Mountain Spotted Fever Symptoms. Centers for Disease Control and Prevention (2015). http://www.cdc.gov/rmsf/symptoms/index.html Accessed on December 30, 2015