Sporotrichosis pathophysiology: Difference between revisions
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===Pathogenesis=== | ===Pathogenesis=== | ||
*The pathophysiology of sporotrichosis depends on the histological subtype and the frequently nonspecific histopathology may mimic other granulomatous diseases.<ref name="pmid25614735">{{cite journal| author=Mahajan VK| title=Sporotrichosis: an overview and therapeutic options. | journal=Dermatol Res Pract | year= 2014 | volume= 2014 | issue= | pages= 272376 | pmid=25614735 | doi=10.1155/2014/272376 | pmc=PMC4295339 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25614735 }} </ref> | *The pathophysiology of sporotrichosis depends on the histological subtype and the frequently nonspecific histopathology may mimic other granulomatous diseases.<ref name="pmid25614735">{{cite journal| author=Mahajan VK| title=Sporotrichosis: an overview and therapeutic options. | journal=Dermatol Res Pract | year= 2014 | volume= 2014 | issue= | pages= 272376 | pmid=25614735 | doi=10.1155/2014/272376 | pmc=PMC4295339 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25614735 }} </ref> | ||
Cutaneous forms | ====Cutaneous forms==== | ||
:* ''S. schecknii'' accesses the subcutaneous tissue following minor epidermal trauma. | :* ''S. schecknii'' accesses the subcutaneous tissue following minor epidermal trauma. | ||
:* ''S. schecknii,'' a thermo-dependent fungus, converts into its yeast form upon entering the tissue. | :* ''S. schecknii,'' a thermo-dependent fungus, converts into its yeast form upon entering the tissue. | ||
| Line 22: | Line 22: | ||
* Disseminated cutaneous form | * Disseminated cutaneous form | ||
** Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''. | ** Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''. | ||
Extracutaneous/Systematic Forms | ====Extracutaneous/Systematic Forms==== | ||
*Osteoarticular form | *Osteoarticular form | ||
**May manifest upon contiguity or hematogenous spread. | **May manifest upon contiguity or hematogenous spread. | ||
Revision as of 18:08, 13 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Alison Leibowitz [2]
Overview
Pathophysiology
Transmission
- S. schenckii is usually transmitted to the human host via posttraumatic inoculation. However, sporotrichosis may also develop as a result of spore inhalation, although this mode of transmission is infrequent.
- Modes of transmission either lead to direct inoculation or enable the entry of the fungus.
- Actions, such as handling thorny plants, sphagnum moss, bales of hay, or any plant or plant product that can cause skin trauma, may enable S. schenckii entry.
Pathogenesis
- The pathophysiology of sporotrichosis depends on the histological subtype and the frequently nonspecific histopathology may mimic other granulomatous diseases.[1]
Cutaneous forms
- S. schecknii accesses the subcutaneous tissue following minor epidermal trauma.
- S. schecknii, a thermo-dependent fungus, converts into its yeast form upon entering the tissue.
- Fixed form
- The yeast form of S. schenckii stays localized in subcutaneous tissue
- Lymphocutaneous form
- The yeast form of S. schenckii extends through the nearby lymphatic vessels
- Disseminated cutaneous form
- Manifests upon the hematogenous dissemination of the yeast form of S. schenckii.
Extracutaneous/Systematic Forms
- Osteoarticular form
- May manifest upon contiguity or hematogenous spread.
- Pulmonary form
- Manifests following inhalation of S. schenckii spores
- Disseminated form
- Manifests upon the hematogenous dissemination of the yeast form of S. schenckii.
References
- ↑ Mahajan VK (2014). "Sporotrichosis: an overview and therapeutic options". Dermatol Res Pract. 2014: 272376. doi:10.1155/2014/272376. PMC 4295339. PMID 25614735.