Sporotrichosis pathophysiology: Difference between revisions
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**Manifests following inhalation of ''S. schenckii'' spores | **Manifests following inhalation of ''S. schenckii'' spores | ||
*Disseminated form | *Disseminated form | ||
**Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''. | **Manifests upon the hematogenous dissemination of the yeast form of ''S. schenckii''.<ref name="pmid21976602">{{cite journal| author=Barros MB, de Almeida Paes R, Schubach AO| title=Sporothrix schenckii and Sporotrichosis. | journal=Clin Microbiol Rev | year= 2011 | volume= 24 | issue= 4 | pages= 633-54 | pmid=21976602 | doi=10.1128/CMR.00007-11 | pmc=PMC3194828 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21976602 }} </ref> | ||
==References== | ==References== | ||
Revision as of 18:19, 13 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Alison Leibowitz [2]
Overview
Pathophysiology
Transmission
- S. schenckii is usually transmitted to the human host via posttraumatic inoculation. However, sporotrichosis may also develop as a result of spore inhalation, although this mode of transmission is infrequent.
- Modes of transmission either lead to direct inoculation or enable the entry of the fungus.
- Actions, such as handling thorny plants, sphagnum moss, bales of hay, or any plant or plant product that can cause skin trauma, may enable S. schenckii entry.
Pathogenesis
- The pathophysiology of sporotrichosis depends on the histological subtype and the frequently nonspecific histopathology may mimic other granulomatous diseases.[1]
Cutaneous forms
- S. schecknii accesses the subcutaneous tissue following minor epidermal trauma.
- S. schecknii, a thermo-dependent fungus, converts into its yeast form upon entering the tissue.
- Fixed form
- The yeast form of S. schenckii stays localized in subcutaneous tissue
- Lymphocutaneous form
- The yeast form of S. schenckii extends through the nearby lymphatic vessels
- Disseminated cutaneous form
- Manifests upon the hematogenous dissemination of the yeast form of S. schenckii.
Extracutaneous/Systematic Forms
- Osteoarticular form
- May manifest upon contiguity or hematogenous spread.
- Pulmonary form
- Manifests following inhalation of S. schenckii spores
- Disseminated form
- Manifests upon the hematogenous dissemination of the yeast form of S. schenckii.[2]
References
- ↑ Mahajan VK (2014). "Sporotrichosis: an overview and therapeutic options". Dermatol Res Pract. 2014: 272376. doi:10.1155/2014/272376. PMC 4295339. PMID 25614735.
- ↑ Barros MB, de Almeida Paes R, Schubach AO (2011). "Sporothrix schenckii and Sporotrichosis". Clin Microbiol Rev. 24 (4): 633–54. doi:10.1128/CMR.00007-11. PMC 3194828. PMID 21976602.