Neoplastic meningitis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Causes

• Primary intracerebral malignancies that may cause metastases to the subarachnoid space include:

• Glioblastoma multiforme
• Anaplastic astrocytoma
• Medulloblastoma
• Supratentorial primitive neuroectodermal tumors
• Ependymoma
• Germinoma
• Choroid plexus carcinoma

• Vast majority of leptomeningeal metastases originates from a widespread metastatic disease (hematogenic spread). Common primary sites include:

• Breast cancer (most common)
• Lung cancer
• Melanoma
• Lymphoma and leukemia

• Sarcomas rarely metastasizes to the meninges.

References

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