Linitis plastica primary prevention: Difference between revisions
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==Overview== | ==Overview== | ||
Effective measure for the [[primary prevention]] of hereditary diffuse gastric [[adenocarcinoma]] includes prophylactic [[gastrectomy]] in individuals who test positive for ''CDH1'' [[gene]] [[mutation]]s.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348 }} </ref> | Effective measure for the [[primary prevention]] of hereditary diffuse gastric [[adenocarcinoma]] includes prophylactic [[gastrectomy]] in individuals who test positive for ''CDH1'' [[gene]] [[mutation]]s.<ref name="pmid20719348">{{cite journal| author=Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS| title=Prophylactic total gastrectomy for individuals with germline CDH1 mutation. | journal=Surgery | year= 2011 | volume= 149 | issue= 3 | pages= 347-55 | pmid=20719348 | doi=10.1016/j.surg.2010.07.005 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20719348 }} </ref> | ||
[[Genetic testing]] can be carried out in those who have family history of hereditary diffuse gastric [[adenocarcinoma]] and are postive for [[CDH1 (gene)|CDH1 gene]] mutation. The risk for developing [[Stomach cancer|gastric cancer]] is high enough to warrant prophylactic [[gastrectomy]] in these patients. | |||
==Primary Prevention== | ==Primary Prevention== | ||
Revision as of 21:36, 11 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Effective measure for the primary prevention of hereditary diffuse gastric adenocarcinoma includes prophylactic gastrectomy in individuals who test positive for CDH1 gene mutations.[1] Genetic testing can be carried out in those who have family history of hereditary diffuse gastric adenocarcinoma and are postive for CDH1 gene mutation. The risk for developing gastric cancer is high enough to warrant prophylactic gastrectomy in these patients.
Primary Prevention
Effective measure for the primary prevention of hereditary diffuse gastric adenocarcinoma includes prophylactic gastrectomy in individuals who test positive for CDH1 gene mutations.[1]
References
- ↑ 1.0 1.1 Pandalai PK, Lauwers GY, Chung DC, Patel D, Yoon SS (2011). "Prophylactic total gastrectomy for individuals with germline CDH1 mutation". Surgery. 149 (3): 347–55. doi:10.1016/j.surg.2010.07.005. PMID 20719348.