Linitis plastica natural history, complications and prognosis: Difference between revisions
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If left untreated, patients with linitis plastica may progress to develop symptoms from decreased [[peristalsis]] of the stomach that may include [[dyspepsia]], [[dysphagia]], nausea, vomiting, increased satiety, and [[regurgitation]].<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref><ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of [[metastasis]] is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.<ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> | If left untreated, patients with linitis plastica may progress to develop symptoms from decreased [[peristalsis]] of the stomach that may include [[dyspepsia]], [[dysphagia]], nausea, vomiting, increased satiety, and [[regurgitation]].<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref><ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of [[metastasis]] is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.<ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> | ||
==Natural | ==Natural History== | ||
*Diffuse gastric [[adenocarcinoma]] or linitis plastica remains asymptomatic for a long time before diagnosis. Therefore, when a patient presents with symptoms, the disease is usually in an advanced stage.<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref> | *Diffuse gastric [[adenocarcinoma]] or linitis plastica remains asymptomatic for a long time before diagnosis. Therefore, when a patient presents with symptoms, the disease is usually in an advanced stage.<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref> | ||
*If left untreated, patients with linitis plastica may progress to develop symptoms from decreased [[peristalsis]] of the stomach and may include [[dyspepsia]], [[dysphagia]], nausea, vomiting, increased satiety, and [[regurgitation]].<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref><ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> | *If left untreated, patients with linitis plastica may progress to develop symptoms from decreased [[peristalsis]] of the stomach and may include [[dyspepsia]], [[dysphagia]], nausea, vomiting, increased satiety, and [[regurgitation]].<ref name="pmid23984032">{{cite journal| author=Jafferbhoy S, Shiwani H, Rustum Q| title=Managing Gastric Linitis Plastica: Keep the scalpel sheathed. | journal=Sultan Qaboos Univ Med J | year= 2013 | volume= 13 | issue= 3 | pages= 451-3 | pmid=23984032 | doi= | pmc=PMC3749031 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23984032 }} </ref><ref name=og>Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach that may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.[1][2] Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.[2]
Natural History
- Diffuse gastric adenocarcinoma or linitis plastica remains asymptomatic for a long time before diagnosis. Therefore, when a patient presents with symptoms, the disease is usually in an advanced stage.[1]
- If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach and may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.[1][2]
Complications
Patients with linitis plastica may progress to develop gastric outlet obstruction from the rigid stomach wall that limits the process of digestion.[3]
Prognosis
- Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary.
- The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica because of the rapid peritoneal and lymphatic spread of the disease.
- Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.[2]
References
- ↑ 1.0 1.1 1.2 Jafferbhoy S, Shiwani H, Rustum Q (2013). "Managing Gastric Linitis Plastica: Keep the scalpel sheathed". Sultan Qaboos Univ Med J. 13 (3): 451–3. PMC 3749031. PMID 23984032.
- ↑ 2.0 2.1 2.2 2.3 Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.
- ↑ Shiver SA, Blaivas M (2004). "Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography". J Ultrasound Med. 23 (7): 989–92. PMID 15292571.