Linitis plastica causes: Difference between revisions
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{{Linitis plastica}} | {{Linitis plastica}} | ||
{{CMG}}{{AE}} {{ | {{CMG}};{{AE}}{{HM}} | ||
==Overview== | ==Overview== | ||
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by secondary metastasis to the stomach or by the ingestion of lye. | |||
==Causes== | ==Causes== | ||
===Primary Causes=== | |||
*Linitis plastica | *Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.<ref name="pmid14630673">{{cite journal |vauthors=Graziano F, Humar B, Guilford P |title=The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice |journal=Ann. Oncol. |volume=14 |issue=12 |pages=1705–13 |year=2003 |pmid=14630673 |doi= |url=}}</ref> | ||
* [[Somatic]] [[mutations]] in the ''CDH1'' [[gene]] can occur by: | |||
**Hypermethylation | |||
**[[Loss of heterozygosity]] | |||
**Silencing mutations | |||
===Secondary causes=== | |||
*Lye ingestion | |||
*Metastatic infiltration of the stomach by: | |||
**Lung cancer | |||
**Breast cancer | |||
**Non-hodgkins lymphoma | |||
==References== | ==References== | ||
Revision as of 16:56, 8 January 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Hadeel Maksoud M.D.[2]
Overview
Linitis plastica may develop as a primary or secondary pathology. As a primary pathology, linitis plastica may be due to defective intracellular adhesions caused by germline truncations mutation in CDH1 gene. CDH1 gene codes for E-cadherin adhesion protein. Secondarily, linitis plastica may be caused by secondary metastasis to the stomach or by the ingestion of lye.
Causes
Primary Causes
- Linitis plastica can develop in an autosomal dominant pattern by a mutation in the CDH1 gene.[1]
- Somatic mutations in the CDH1 gene can occur by:
- Hypermethylation
- Loss of heterozygosity
- Silencing mutations
Secondary causes
- Lye ingestion
- Metastatic infiltration of the stomach by:
- Lung cancer
- Breast cancer
- Non-hodgkins lymphoma