Neoplastic meningitis natural history, complications and prognosis: Difference between revisions
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*The median survival time of patients without treatment of neoplastic meningitis is 4-6 weeks.<ref name=prognosisnm123>Prognosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref> | *The median survival time of patients without treatment of neoplastic meningitis is 4-6 weeks.<ref name=prognosisnm123>Prognosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref> | ||
*Neoplastic meningitis due to breast cancer has the best prognosis, where the median survival time is approximately 6 months after diagnosis.<ref name=prognosisnm123>Prognosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref> | *Neoplastic meningitis due to breast cancer has the best prognosis, where the median survival time is approximately 6 months after diagnosis.<ref name=prognosisnm123>Prognosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016</ref> | ||
*Favorable prognostic factors for neoplastic meningitis include:<ref name=prognosisnmiugkjh>{{cite journal| last= Balm | first= M. | last= Hammack | first=J. | title= Leptomeningeal Carcinomatosis | *Favorable prognostic factors for neoplastic meningitis include:<ref name=prognosisnmiugkjh>{{cite journal| last= Balm | first= M. | last= Hammack | first=J. | title= Leptomeningeal Carcinomatosis Presenting Features and Prognostic Factors| doi=10.1001/archneur.1996.00550070064013.| Date= 01/22/2016}}</ref> | ||
Presenting Features and Prognostic Factors| doi=10.1001/archneur.1996.00550070064013.| Date= 01/22/2016}}</ref> | |||
:*Female gender | :*Female gender | ||
:*Longer duration of neurological symptoms | :*Longer duration of neurological symptoms | ||
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:*High Cyfra 21-1 level at diagnosis | :*High Cyfra 21-1 level at diagnosis | ||
::*Cyfra 21-1 is a fragment of the cytokeratin-19 and may reflect the tumor burden within the cerebrospinal fluid. | ::*Cyfra 21-1 is a fragment of the cytokeratin-19 and may reflect the tumor burden within the cerebrospinal fluid. | ||
*Neoplastic meningitis patients treated with intra-CSF chemotherapy have a better prognosis.<ref name=prognosisnmiugkjh>{{cite journal| last= Balm | first= M. | last= Hammack | first=J. | title= Leptomeningeal Carcinomatosis Presenting Features and Prognostic Factors| doi=10.1001/archneur.1996.00550070064013.| Date= 01/22/2016}}</ref> | |||
==References== | ==References== | ||
Revision as of 15:50, 22 January 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
- Neoplastic meningitis has a widely disseminated and progressive presentation.
Complications
Complications of neoplastic meningitis include:[1]
- Hydrocephalus
- Encephalopathy
- Subdural empyema
- Epidural empyema
- Cerebritis
- Cerebral abscess
- Stroke
- Ventriculitis
- Dural sinus thrombosis
Prognosis
- The median survival time of patients without treatment of neoplastic meningitis is 4-6 weeks.[2]
- Neoplastic meningitis due to breast cancer has the best prognosis, where the median survival time is approximately 6 months after diagnosis.[2]
- Favorable prognostic factors for neoplastic meningitis include:[3]
- Female gender
- Longer duration of neurological symptoms
- Absence of cerebral leptomeningeal clinical involvement
- Absence of elevated CSF protein
- Poor prognostic factors for neoplastic meningitis include:[2]
- Negative hormone receptor status
- Poor performance status
- Multiple fixed neurological deficits
- Coexistent carcinomatous encephalopathy
- More than 3 chemotherapy regimes
- High Cyfra 21-1 level at diagnosis
- Cyfra 21-1 is a fragment of the cytokeratin-19 and may reflect the tumor burden within the cerebrospinal fluid.
- Neoplastic meningitis patients treated with intra-CSF chemotherapy have a better prognosis.[3]
References
- ↑ Complications of leptomeningitis. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/leptomeningitis. Accessed on January 21, 2016
- ↑ 2.0 2.1 2.2 Prognosis of neoplastic meningitis. Wikipedia 2016. https://en.wikipedia.org/wiki/Neoplastic_meningitis. Accessed on January 20, 2016
- ↑ 3.0 3.1 Hammack, J. "Leptomeningeal Carcinomatosis Presenting Features and Prognostic Factors". doi:10.1001/archneur.1996.00550070064013. Check
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