Sandbox: ATL

prognosis

Clinical form age poor clinical performance status high lactate dehydrogenase (LDH) high β2‐microglobulin high leukemic counts hypercalcemia high serum level of CD25 high serum neuron‐specific enolase

Prognostic Factor	Description
Age	Older age at the time of diagnosis is associated with a worse prognosis.
Gender	Males are associated with a worse prognosis when compared to females.
Performance status	Patient's poor performance status is associated with a worse prognosis.
Stage	Binet stages B and C or Rai stages 2-4 are associated with a worse prognosis.
Lymphocyte doubling time	A rapid lymphocyte doubling time is associated with a worse prognosis.
Genetic mutations	Deletion of chromosome 17 short arm and chromosome 11 long arm are associated with a worse prognosis.
Prolymphocytes percent	An increased percentage of prolymphocytes is associated with a worse prongnosis.
Histological analysis	Diffuse histology on bone marrow aspiration is associated with a worse prognosis.
Lactate dehydrogenase (LDH) level	Elevated level of LDH is associated with a worse prognosis.
β2-microglobulin level	Elevated level of β2-microglobulin level is associated with a worse prognosis.
Lymphocyte surface markers	Over expression of CD38 is associated with a worse prognosis.
Immunoglobulin (Ig)VH gene	The absence of IgVH gene mutation is associated with a worse prognosis.
Membrane-bound proteins	The expression of zeta-chain-associated protein kinase 70 (ZAP) is associated with a worse prognosis.