Sandbox: ATL: Difference between revisions
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===prognosis=== | ===prognosis=== | ||
high lactate dehydrogenase (LDH) | high lactate dehydrogenase (LDH) | ||
high β2‐microglobulin | high β2‐microglobulin | ||
high serum level of CD25 | high serum level of CD25 | ||
high serum neuron‐specific enolase | high serum neuron‐specific enolase | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Clinical form'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
:* Older age at the time of diagnosis is associated with a worse prognosis. | :* Older age at the time of diagnosis is associated with a worse prognosis. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Age'''|| style="padding: 5px 5px; background: #F5F5F5;"| | ||
:* Males are associated with a worse prognosis when compared to females. | :* Males are associated with a worse prognosis when compared to females. | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Calcium level'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
:*Binet stages B and C or Rai stages 2-4 are associated with a worse prognosis. | :*Binet stages B and C or Rai stages 2-4 are associated with a worse prognosis. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Leukocyte count'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
:*A rapid [[lymphocyte]] doubling time is associated with a worse prognosis. | :*A rapid [[lymphocyte]] doubling time is associated with a worse prognosis. | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lactate dehydrogenase level'''|| style="padding: 5px 5px; background: #F5F5F5;"| | ||
:*Deletion of [[chromosome 17]] short arm and [[chromosome 11]] long arm are associated with a worse prognosis. | :*Deletion of [[chromosome 17]] short arm and [[chromosome 11]] long arm are associated with a worse prognosis. | ||
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|style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | |style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''β2-microglobulin level'''|| style="padding: 5px 5px; background: #F5F5F5;" | | ||
:*An increased percentage of [[prolymphocyte]]s is associated with a worse prongnosis. | :*An increased percentage of [[prolymphocyte]]s is associated with a worse prongnosis. | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lymphocyte surface markers'''|| style="padding: 5px 5px; background: #F5F5F5;"| | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Lymphocyte surface markers'''|| style="padding: 5px 5px; background: #F5F5F5;"| | ||
:*Over expression of [[ | :*Over expression of [[CD25]] is associated with a worse prognosis. | ||
|- | |- | ||
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | ''' | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center | '''Neuron‐specific enolase'''|| style="padding: 5px 5px; background: #F5F5F5;"| | ||
:*The absence of IgVH [[gene]] mutation is associated with a worse prognosis. | :*The absence of IgVH [[gene]] mutation is associated with a worse prognosis. | ||
Revision as of 19:56, 24 January 2016
prognosis
high lactate dehydrogenase (LDH) high β2‐microglobulin
high serum level of CD25 high serum neuron‐specific enolase
Prognostic Factor | Description |
---|---|
Clinical form |
|
Age |
|
Performance status |
|
Calcium level |
|
Leukocyte count |
|
Lactate dehydrogenase level |
|
β2-microglobulin level |
|
Histological analysis |
|
Lactate dehydrogenase (LDH) level |
|
β2-microglobulin level |
|
Lymphocyte surface markers |
|
Neuron‐specific enolase |
|
Membrane-bound proteins |
|
- ↑ Mahieux R, Gessain A (2007). "Adult T-cell leukemia/lymphoma and HTLV-1". Curr Hematol Malig Rep. 2 (4): 257–64. doi:10.1007/s11899-007-0035-x. PMID 20425378.
- ↑ Matutes E (2007). "Adult T-cell leukaemia/lymphoma". J Clin Pathol. 60 (12): 1373–7. doi:10.1136/jcp.2007.052456. PMC 2095573. PMID 18042693.
- ↑ Katsuya H, Ishitsuka K, Utsunomiya A, Hanada S, Eto T, Moriuchi Y; et al. (2015). "Treatment and survival among 1594 patients with ATL". Blood. 126 (24): 2570–7. doi:10.1182/blood-2015-03-632489. PMID 26361794.