Sandbox: ATL: Difference between revisions
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* Adult T-cell lymphoma patients are usually managed by either chemotherapy, supportive care, or allogeneic stem cell transplant. | * Adult T-cell lymphoma patients are usually managed by either chemotherapy, supportive care, or allogeneic stem cell transplant. | ||
===Chronic/Smoldering Adult T-cell Leukemia Management=== | ===Chronic/Smoldering Adult T-cell Leukemia Management=== | ||
* Patients may be managed by observation and close follow-up for any symptomatic deterioration. Follow up tests for such patients may include: | |||
:* Complete history and physical examination | |||
:* Serum calcium level | |||
:* Blood urea nitrogen | |||
:* Serum creatinine level | |||
:* Serum LDH | |||
:* Chest and abdominal CT scan | |||
* Skin directed therapies for the management of localized cutaneous lesions among such patients may include: | |||
:* Topical corticosteroids | |||
:* Topical chemotherapy (mechlorethamine [nitrogen mustard]) | |||
:* Local radiation (8–36 Gy) | |||
:* Topical retinoids (bexarotene, tazarotene) | |||
:* Phototherapy (UVB, NB-UVB for patch/thin plaques; PUVA for thicker plaques) | |||
:* Topical imiquimod | |||
* Zidovudine and interferon combination therapy: | |||
:* Chronic/smoldering adult T-cell leukemia patients should be evaluated for response after two months of initiating the combination therapy. | |||
:* Responders should be continued on zidovudine and interferon therapy. | |||
:* While non-responders should be managed by either chemotherapy or supportive care depending on the patients preference. |
Revision as of 17:16, 25 January 2016
- The optimal therapy for adult T-cell leukemia depends on the clinical variant of the disease.
- Chronic and smoldering adult T-cell leukemia patients are usually managed by either observation, skin directed therapies, or a combination of idovudine and interferon therapy.
- Acute adult T-cell leukemia patients are usually managed by either chemotherapy, supportive care, allogeneic stem cell transplant, or a combination of zidovudine and interferon therapy.
- Adult T-cell lymphoma patients are usually managed by either chemotherapy, supportive care, or allogeneic stem cell transplant.
Chronic/Smoldering Adult T-cell Leukemia Management
- Patients may be managed by observation and close follow-up for any symptomatic deterioration. Follow up tests for such patients may include:
- Complete history and physical examination
- Serum calcium level
- Blood urea nitrogen
- Serum creatinine level
- Serum LDH
- Chest and abdominal CT scan
- Skin directed therapies for the management of localized cutaneous lesions among such patients may include:
- Topical corticosteroids
- Topical chemotherapy (mechlorethamine [nitrogen mustard])
- Local radiation (8–36 Gy)
- Topical retinoids (bexarotene, tazarotene)
- Phototherapy (UVB, NB-UVB for patch/thin plaques; PUVA for thicker plaques)
- Topical imiquimod
- Zidovudine and interferon combination therapy:
- Chronic/smoldering adult T-cell leukemia patients should be evaluated for response after two months of initiating the combination therapy.
- Responders should be continued on zidovudine and interferon therapy.
- While non-responders should be managed by either chemotherapy or supportive care depending on the patients preference.