Sandbox: Langerhans: Difference between revisions

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LCH is a rare disease,  
LCH is a rare disease,  
affecting approximately 5 to 6 persons per 1 million people annually in the United States
It is primarily encountered in pediatric patients; 50% to 90% of cases are diagnosed between the ages of 1 year and 15 years.


* The incidence of Langerhans cell histiocytosis is approximately 5  per 1,000,000 individuals in the United States.
* Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.
* Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.
* The median age at diagnosis is depends on the specific subtype of the disease, such as:
* The median age at diagnosis is depends on the specific subtype of the disease, such as:
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:* Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
:* Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
:* Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
:* Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
 
* Males are more commonly affected with Langerhans cell histiocytosis than females. The male to female ratio is approximately 2 to 1.
 
 
 
Patients with isolated EG bone lesions typically present at age 5 to 15 years, whereas those with systemic forms of LCH present earlier (age 1 year to 5 years).
These lesions predominantly affect males, with a male-to-female ratio of 2 to 3:1 reported.

Revision as of 15:12, 4 February 2016

LCH is a rare disease,


  • The incidence of Langerhans cell histiocytosis is approximately 5 per 1,000,000 individuals in the United States.
  • Langerhans cell histiocytosis commonly affects individuals younger than 15 years of age.
  • The median age at diagnosis is depends on the specific subtype of the disease, such as:
  • Pulmonary Langerhans cell histiocytosis is usually first diagnosed among adults.
  • Unifocal Langerhans cell histiocytosis and multifocal unisystem Langerhans cell histiocytosis are usually first diagnosed among individuals of 2-10 years of age.
  • Multifocal multisystem Langerhans cell histiocytosis is usually first diagnosed among individuals younger than 2 years of age.
  • Males are more commonly affected with Langerhans cell histiocytosis than females. The male to female ratio is approximately 2 to 1.