Langerhans cell histiocytosis laboratory tests: Difference between revisions

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Revision as of 21:51, 4 February 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

@@ Line 12: / Line 12: @@
 ====Basic Metabolic Panel====
+* Elevated [[bilirubin]] concentration
+* Abnormal [[liver]] enzymes
+* Elevated [[alkaline phosphatase]]
 ====Urinalysis====
 ====Immunohistochemistry====
-*Diagnosis of LCH is confirmed [[histologically]] by [[tissue]] [[biopsy]].
+* On immunohistochemistry Langerhans cell histiocytosis is characterized by:
-*Haemotoxilin-eosin stain of biopsy slide will show features of Langerhans cell e.g. distinct cell margin, pink granular [[cytoplasm]]. Presence of [[Birbeck granules]] on [[electron microscopy]] and [[immuno-cytochemistry|immuno-cytochemical]] features e. g. [[CD1]] positivity are more specific.
+:* [[CD1a]] +ve
-*Initially routine blood tests e.g. full blood count, liver function test, U&Es, bone profile are done to determine disease extent and rule out other causes.
+:* S100 +ve
-*Assessment of [[endocrine]] function and bone marrow biopsy are also performed when indicated.
+:* CD207 (langerin) +ve
 ==References==