Extramammary Paget's disease medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Chemotherapy therapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease. | Chemotherapy therapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.<ref name="pmid19691751">{{cite journal| author=Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H et al.| title=Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy. | journal=J Dermatol | year= 2009 | volume= 36 | issue= 8 | pages= 457-61 | pmid=19691751 | doi=10.1111/j.1346-8138.2009.00676.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19691751 }} </ref><ref name="pmid19840203">{{cite journal| author=Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R et al.| title=Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule. | journal=J Eur Acad Dermatol Venereol | year= 2010 | volume= 24 | issue= 4 | pages= 490-2 | pmid=19840203 | doi=10.1111/j.1468-3083.2009.03451.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840203 }} </ref><ref name="pmid25259595">{{cite journal| author=Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A et al.| title=Treatment of primary vulvar paget disease with 5% imiquimod cream. | journal=J Low Genit Tract Dis | year= 2014 | volume= 18 | issue= 4 | pages= 347-50 | pmid=25259595 | doi=10.1097/LGT.0000000000000053 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25259595 }} </ref><ref name="pmid19862365">{{cite journal| author=Beleznay KM, Levesque MA, Gill S| title=Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. | journal=Curr Oncol | year= 2009 | volume= 16 | issue= 5 | pages= 81-3 | pmid=19862365 | doi= | pmc=PMC2768510 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19862365 }} </ref> | ||
==Medical Therapy== | ==Medical Therapy== | ||
The following medical therapies have been studied for the treatment of extramammary Paget's disease:<ref name="pmid19691751">{{cite journal| author=Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H et al.| title=Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy. | journal=J Dermatol | year= 2009 | volume= 36 | issue= 8 | pages= 457-61 | pmid=19691751 | doi=10.1111/j.1346-8138.2009.00676.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19691751 }} </ref><ref name="pmid19840203">{{cite journal| author=Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R et al.| title=Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule. | journal=J Eur Acad Dermatol Venereol | year= 2010 | volume= 24 | issue= 4 | pages= 490-2 | pmid=19840203 | doi=10.1111/j.1468-3083.2009.03451.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840203 }} </ref><ref name="pmid25259595">{{cite journal| author=Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A et al.| title=Treatment of primary vulvar paget disease with 5% imiquimod cream. | journal=J Low Genit Tract Dis | year= 2014 | volume= 18 | issue= 4 | pages= 347-50 | pmid=25259595 | doi=10.1097/LGT.0000000000000053 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25259595 }} </ref><ref name="pmid19862365">{{cite journal| author=Beleznay KM, Levesque MA, Gill S| title=Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain. | journal=Curr Oncol | year= 2009 | volume= 16 | issue= 5 | pages= 81-3 | pmid=19862365 | doi= | pmc=PMC2768510 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19862365 }} </ref> | |||
*[[5-fluorouracil]] | |||
*[[Imiquimod]] | |||
*Combination of [[paclitaxel]] and [[trastuzumab]] | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:03, 5 February 2016
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Extramammary Paget's disease Microchapters |
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Differentiating Extramammary Paget's disease from other Diseases |
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Extramammary Paget's disease medical therapy On the Web |
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Directions to Hospitals Treating Extramammary Paget's disease |
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Risk calculators and risk factors for Extramammary Paget's disease medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chemotherapy therapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.[1][2][3][4]
Medical Therapy
The following medical therapies have been studied for the treatment of extramammary Paget's disease:[1][2][3][4]
- 5-fluorouracil
- Imiquimod
- Combination of paclitaxel and trastuzumab
References
- ↑ 1.0 1.1 Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H; et al. (2009). "Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy". J Dermatol. 36 (8): 457–61. doi:10.1111/j.1346-8138.2009.00676.x. PMID 19691751.
- ↑ 2.0 2.1 Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R; et al. (2010). "Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule". J Eur Acad Dermatol Venereol. 24 (4): 490–2. doi:10.1111/j.1468-3083.2009.03451.x. PMID 19840203.
- ↑ 3.0 3.1 Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A; et al. (2014). "Treatment of primary vulvar paget disease with 5% imiquimod cream". J Low Genit Tract Dis. 18 (4): 347–50. doi:10.1097/LGT.0000000000000053. PMID 25259595.
- ↑ 4.0 4.1 Beleznay KM, Levesque MA, Gill S (2009). "Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain". Curr Oncol. 16 (5): 81–3. PMC 2768510. PMID 19862365.