Extramammary Paget's disease medical therapy: Difference between revisions
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*Combination of [[paclitaxel]] and [[trastuzumab]] | *Combination of [[paclitaxel]] and [[trastuzumab]] | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Medication}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Mechanism of action}} | |||
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Dosage}} | |||
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:Imiquimod | |||
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*These agents modulate key factors of the immune system | |||
*Imiquimod is a immune response modifier with an unknown mechanism of action | |||
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*Imiquimod 5% cream is applied 3 times weekly for 16 weeks. | |||
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:Fluorouracil | |||
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*These agents inhibit cell growth and proliferation | |||
*Fluorouracil interferes with DNA synthesis by blocking methylation of deoxyuridylic acid via inhibition of thymidylate synthetase and, eventually, cell proliferation. | |||
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*It is used topically | |||
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:Small localised tumors | |||
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*85-90% | |||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 23:10, 5 February 2016
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Extramammary Paget's disease Microchapters |
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Differentiating Extramammary Paget's disease from other Diseases |
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Extramammary Paget's disease medical therapy On the Web |
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American Roentgen Ray Society Images of Extramammary Paget's disease medical therapy |
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Directions to Hospitals Treating Extramammary Paget's disease |
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Risk calculators and risk factors for Extramammary Paget's disease medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Chemotherapy therapy with either 5-fluorouracil, imiquimod cream, or the combination of paclitaxel and trastuzumab may be helpful in the treatment of extramammary Paget's disease.[1][2][3][4]
Medical Therapy
The following medical therapies have been studied for the treatment of extramammary Paget's disease:[1][2][3][4]
- 5-fluorouracil
- Imiquimod
- Combination of paclitaxel and trastuzumab
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References
- ↑ 1.0 1.1 Takahagi S, Noda H, Kamegashira A, Madokoro N, Hori I, Shindo H; et al. (2009). "Metastatic extramammary Paget's disease treated with paclitaxel and trastuzumab combination chemotherapy". J Dermatol. 36 (8): 457–61. doi:10.1111/j.1346-8138.2009.00676.x. PMID 19691751.
- ↑ 2.0 2.1 Sendagorta E, Herranz P, Feito M, Ramírez P, Floristán U, Feltes R; et al. (2010). "Successful treatment of three cases of primary extramammary Paget's disease of the vulva with Imiquimod--proposal of a therapeutic schedule". J Eur Acad Dermatol Venereol. 24 (4): 490–2. doi:10.1111/j.1468-3083.2009.03451.x. PMID 19840203.
- ↑ 3.0 3.1 Marchitelli C, Peremateu MS, Sluga MC, Berasategui MT, Lopez DG, Wernicke A; et al. (2014). "Treatment of primary vulvar paget disease with 5% imiquimod cream". J Low Genit Tract Dis. 18 (4): 347–50. doi:10.1097/LGT.0000000000000053. PMID 25259595.
- ↑ 4.0 4.1 Beleznay KM, Levesque MA, Gill S (2009). "Response to 5-fluorouracil in metastatic extramammary Paget disease of the scrotum presenting as pancytopenia and back pain". Curr Oncol. 16 (5): 81–3. PMC 2768510. PMID 19862365.