Mesothelioma other diagnostic studies: Difference between revisions
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===Fluorescence In Situ Hybridization (FISH)=== | ===Fluorescence In Situ Hybridization (FISH)=== | ||
*[[FISH]] may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | *[[FISH]] may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | ||
*Mutlitarget FISH assay may be used to detect chromosomal abberations ([[chromosome 3|chromosomes 3]], [[chromosome 7|7]], chromosome 17|17]], and [[chromosome 9|9p21]]).<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | *Mutlitarget FISH assay may be used to detect chromosomal abberations ([[chromosome 3|chromosomes 3]], [[chromosome 7|7]], [[chromosome 17|17]], and [[chromosome 9|9p21]]). | ||
*FISH technique may also be used to explore the alternative mechanism of [[tumor suppressor gene]] inactivation by methylation of ''[[p16]]'', ''p14'', and ''p15'' gene in the pathogenesis of mesothelioma.<ref name="pmid20139227">{{cite journal| author=Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B et al.| title=Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology. | journal=Chest | year= 2010 | volume= 138 | issue= 1 | pages= 137-44 | pmid=20139227 | doi=10.1378/chest.09-1951 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20139227 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:13, 15 February 2016
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Mesothelioma Microchapters |
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Mesothelioma other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Mesothelioma other diagnostic studies |
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Risk calculators and risk factors for Mesothelioma other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
- Antibodies to cytokeratin proteins are positive, differentiating these neoplasms from many sarcomas but not adenocarcinomas.
- The absence of staining with CEA or Leu-M1 differentiates them from adenocarcinomas.
- Recent evidence shows that Wilms’ Tumor Antigen 1 may help differentiate mesothelioma from adenocarcinoma.
Other Diagnostic Studies
Position Emission Tomography
- Positron emission tomography is becoming useful in two clinical settings:[1]
- Differentiating between benign and malignant asbestos-related pleural thickening
- Assessing for nodal metastases
- In addition, there appears to be a correlation between the degree of FDG uptake and the biological aggressiveness of the tumor, which may help to guide treatment.[1]
Fluorescence In Situ Hybridization (FISH)
- FISH may be helpful in the diagnosis of mesothelioma. It helps in distinguishing malignant mesothelioma from reactive mesothelial cells in effusions.[2]
- Mutlitarget FISH assay may be used to detect chromosomal abberations (chromosomes 3, 7, 17, and 9p21).
- FISH technique may also be used to explore the alternative mechanism of tumor suppressor gene inactivation by methylation of p16, p14, and p15 gene in the pathogenesis of mesothelioma.[2]
References
- ↑ 1.0 1.1 Radiographic findings of mesothelioma. Dr Bruno Di Muzio and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/mesothelioma. Accessed on February 8, 2015
- ↑ 2.0 2.1 Savic S, Franco N, Grilli B, Barascud Ade V, Herzog M, Bode B; et al. (2010). "Fluorescence in situ hybridization in the definitive diagnosis of malignant mesothelioma in effusion cytology". Chest. 138 (1): 137–44. doi:10.1378/chest.09-1951. PMID 20139227.