Extranodal NK-T-cell lymphoma pathophysiology: Difference between revisions
No edit summary |
No edit summary |
||
| Line 14: | Line 14: | ||
* On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical [[necrosis]] and [[ulceration]] are characteristic findings of extranodal NK-T-cell lymphoma. | * On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical [[necrosis]] and [[ulceration]] are characteristic findings of extranodal NK-T-cell lymphoma. | ||
* [[Coagulative necrosis]] and [[apoptotic]] bodies are frequently encountered. | * [[Coagulative necrosis]] and [[apoptotic]] bodies are frequently encountered. | ||
<gallery widths=200px> | |||
Image:Extranodal NK-T cell lymphoma image 1.jpg| NK/T-cell lymphoma of the nasal type presenting with perforation of hard palate.<ref name=Hindawi>Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016 </ref> | |||
</gallery> | |||
==Microscopic Pathology== | ==Microscopic Pathology== | ||
| Line 19: | Line 23: | ||
* The tumor cells are small to medium in size with occasional large and anaplastic forms. | * The tumor cells are small to medium in size with occasional large and anaplastic forms. | ||
* The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small [[lymphocytes]], [[plasma cells]], [[histiocytes]], and [[eosinophils]]. | * The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small [[lymphocytes]], [[plasma cells]], [[histiocytes]], and [[eosinophils]]. | ||
<gallery widths=200px> | |||
Image:Extranodal NK-T cell lymphoma.jpg|Histology of NK/T-cell lymphoma showing presence of atypical lymphoid cells, which are medium to large in size with irregular and hyperchromatic nuclei.<ref name=Hindawi>Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016 </ref> | |||
</gallery> | |||
Revision as of 15:49, 18 February 2016
|
Extranodal NK-T-cell lymphoma Microchapters |
|
Differentiating Extranodal NK-T-cell lymphoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Extranodal NK-T-cell lymphoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Extranodal NK-T-cell lymphoma pathophysiology |
|
Risk calculators and risk factors for Extranodal NK-T-cell lymphoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma. On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of nonneoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.[1]
Genetics
Immunotype
- The immunophenotype of NK lymphoma cells is classically positive for CD2, CD56, and cytoplasmic CD3 epsilon.
- They are negative for surface CD3. Unlike normal NK cells, the tumor cells are usually negative for CD7 and CD16.
- They express cytotoxic granule associated proteins granzyme B, T-cell restricted intracellular antigen (TIA-1), and perforin.
Gross Pathology
- On gross pathology, angiocentric and angiodestructive pattern of growth with associated geographical necrosis and ulceration are characteristic findings of extranodal NK-T-cell lymphoma.
- Coagulative necrosis and apoptotic bodies are frequently encountered.
-
![NK/T-cell lymphoma of the nasal type presenting with perforation of hard palate.[1]](/images/1/13/Extranodal_NK-T_cell_lymphoma_image_1.jpg)
NK/T-cell lymphoma of the nasal type presenting with perforation of hard palate.[1]
![NK/T-cell lymphoma of the nasal type presenting with perforation of hard palate.[1]](/index.php/File:Extranodal_NK-T_cell_lymphoma_image_1.jpg)
Microscopic Pathology
- On microscopic histopathological analysis, medium sized tumor cells and polymorphic infiltrate of non-neoplastic inflammatory cells are characteristic findings of extranodal NK-T-cell lymphoma.
- The tumor cells are small to medium in size with occasional large and anaplastic forms.
- The lymphoma cells may be admixed with a polymorphic infiltrate of nonneoplastic inflammatory cells including small lymphocytes, plasma cells, histiocytes, and eosinophils.
-
![Histology of NK/T-cell lymphoma showing presence of atypical lymphoid cells, which are medium to large in size with irregular and hyperchromatic nuclei.[1]](/images/c/ce/Extranodal_NK-T_cell_lymphoma.jpg)
Histology of NK/T-cell lymphoma showing presence of atypical lymphoid cells, which are medium to large in size with irregular and hyperchromatic nuclei.[1]
![Histology of NK/T-cell lymphoma showing presence of atypical lymphoid cells, which are medium to large in size with irregular and hyperchromatic nuclei.[1]](/index.php/File:Extranodal_NK-T_cell_lymphoma.jpg)
References
- ↑ 1.0 1.1 1.2 Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type. Hindawi Publishing Corporation. http://www.hindawi.com/journals/ah/2010/627401/. Accessed on February 18, 2016