Primary central nervous system lymphoma pathophysiology: Difference between revisions
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==Microscopic Pathology== | ==Microscopic Pathology== | ||
*The vast majority (>90%) of primary central nervous system lymphoma are | *The vast majority (>90%) of primary central nervous system lymphoma are [[B-cell]] in origin: [[diffuse large B-cell lymphoma]] and [[burkitt lymphoma|high-grade Burkitt-like B-cell lymphoma]]. | ||
*Malignant cells tend to accumulate around blood vessels. | *Malignant cells tend to accumulate around blood vessels. | ||
Revision as of 18:55, 18 February 2016
Primary central nervous system lymphoma Microchapters |
Differentiating Primary Central Nervous System Lymphoma from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Primary central nervous system lymphoma pathophysiology On the Web |
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Risk calculators and risk factors for Primary central nervous system lymphoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathogenesis
Associated Conditions
Gross Pathology
- Primary central nervous system lymphoma presents as a solitary or multiple, well-defined or infiltrating mass lesion/s that can arise in the cortex, white matter, or deep grey matter (more common in low-grade lesions).[1]
- They may demonstrate areas of necrosis, especially in immunodeficient patients.
- Origin of malignant cells is not well understood as intra-axial CNS does not have lymphatic system.[1]
Microscopic Pathology
- The vast majority (>90%) of primary central nervous system lymphoma are B-cell in origin: diffuse large B-cell lymphoma and high-grade Burkitt-like B-cell lymphoma.
- Malignant cells tend to accumulate around blood vessels.
References
- ↑ 1.0 1.1 Pathology of primary central system lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016